Pattern regcognition receptors and signaling pathways in Cryptococcus neoformans

Abstract

Abstract:

Pattern recognition receptors(PRRs) presented on the surface of host innate immune cells recognize the pathogen-associated molecular patterns(PAMPs) of Cryptococcus neoformans after the invasion,which will trigger downstream sinaling pathways and activate nuclear factor-kappa B(NF-κB) in immune cells,ultimately initiating innate and adaptive immunity,inducing the release of correlative inflammatory factors,activating adaptive immune cells such as Th1,Th2,Th17 cells,recruiting macrophage to eliminate Cryptococcus neoformans.Deep insights into PRRs and downstream pathways will contribute to obtain an overall understanding of immune adjustment and provide superior clinical therapys.

Key words: Cryptococcus neoformans, pattern recognition receptors(PRRs), signaling pathway, immunity

CLC Number:

R379.5

LI Ying-fang, PAN Wei-hua. Pattern regcognition receptors and signaling pathways in Cryptococcus neoformans[J]. Chinese Journal of Mycology, 2016, 11(1): 58-61.

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