The diagnosis and therapeutic evaluation of invasive pulmonary aspergillosis in leukemia patients using CT combined with galactomannan test

Abstract

Abstract:

Objective To investigate the role of chest CT image combine serum galactomannan(GM) test as predictors of therapeutic effect in leukemia patients with invasive pulmonary aspergillosis(IPA).Methods In this retrospective study from Jan 2010 to Dec 2012,we analyzed both of chest CT image and GM test in 25 patients classified as "clinical diagnosis" IPA.Result Chest CT image had four kinds of manifestations:nodules with halo sign(17 cases),wedge-shaped consolidation(3 cases),diffuse lesser tubercle(4 cases) and scattered patchy shadows with satellite lesions(1 case).Antifungal treatment was effectivein 15 cases with GM index being down to normal at the same time.In 8 cases in progress,GM index raised accordingly;when new antifungal therapy was accepted and worked well,the GM index was lower down.In 2 cases of inflammation out of control,GM index was positive constantly.Conclusion Chest CT image combine serum GM test can be considered as a valuable tool to monitoring treatment effect in leukemia patient with IPA.

Key words: leukemia, galactomannan, invasive pulmonary aspergillosis, CT

CLC Number:

R446.5

LI Ming, LI Gong-jie, ZHOU Juan, SHENG Fu-geng, QIAO Peng-gang. The diagnosis and therapeutic evaluation of invasive pulmonary aspergillosis in leukemia patients using CT combined with galactomannan test[J]. Chinese Journal of Mycology, 2016, 11(1): 20-23,27.

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