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Chinese Journal of Mycology 2015, Vol. 10  Issue (5): 276-278.

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The effects of tetrandrine on Candida albicans biofilm and germ tube formation

GUO Lan-fang, LIU Da-biao, ZHOU Meng-jie, HUA Teng-jiang   

  1. Department of clinical laboratory, Fourth People's Hospital of Zhenjiang, Zhenjiang 212001
  • Received:2015-04-14 Online:2015-10-28 Published:2015-10-28

Abstract:

Objective To study the effects of tetrandrine(Tet) on Candida albicans biofilm and germ tube formation.Methods Using the XTT method to observe the effect of Tet on C.albicans biofilm.0.01, 0.1, 1μmol/L of Tet and C.albicans suspensions were incubated together, then the rates of bud tube were counted.The experiment was repeated 5 times.Results Tet had obvious inhibitory effects on C.albicans biofilm and the germ tube(P<0.05).The biofilm and germ tube formation inhibition rate was the highest in 1μmol/L of Tet, compared with the negative control group(P<0.05) and the 0.01, 0.1μmol/L groups(P<0.05).Conclusions Tet had inhibitory effect on C.albicans biofilm and germ tube formation.

Key words: tetrandrine, Candida albicans, germ tube, biofilm

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