Advances in the clinical application of sertaconazole nitrate

Abstract

Abstract:

Sertaconazole nitrate is a new broad-spectrum, efficient topical azole antifungal.This paper summarizes its pharmacological action, anti-inflammatory, antipruritic action, antifungal activity, the latest clinical efficacy and safety evaluation in the treatment of dermatophytoses, superficial candidiasis, seborrheic dermatitis and atopic dermatitis etc.Compared with miconazole, clotrimazole, terbinafine etc, sertaconazole cream can provide a better efficacy and tolerability in the treatment of skin tinea and superficial Candidal infections.Its antipruritic action and once-daily application in the light of its pharmacokinetics increase patient adherence and the cure rate.A topical microemulsion-based hydrogel has been developed to enhance permeation of sertaconazole for effective eradication of cutaneous fungal infection.The latest clinical studies suggest that sertaconazole cream may be an excellent alternative therapeutic modality for treating seborrheic dermatitis and atopic dermatitis.

Key words: Sertaconazole nitrate, antifungal, dermatophytoses, superficial candidiasis, seborrheic dermatitis, atopic dermatitis

CLC Number:

R978.5

SUN Yu-lu, ZHANG Rui-li, SU Fang. Advances in the clinical application of sertaconazole nitrate[J]. Chinese Journal of Mycology, 2015, 10(4): 252-256.

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