The research progress on new targets of antifungal candidates

Abstract

Abstract:

Invasive fungal infections are devastating with increasing morbidity and substantial mortality.Unfortunately,classic antifungal agents are limited by their antifungal spectrums,adverse effects,drug-drug interactions,variable pharmacokinetics,and limit types of formulation.Therefore,novel antifungal agents are urgently needed for the treatment of serious invasive fungal infections.It is possible that antifungal agents with novel targets will provide favorable options to treat fungal infections.It has made great development in antifungal agents research recent years,and the exciting advances are represented by four clusters of antifungal candidates.The first is the novel approach of candidates that destroy fungal cell walls,like E1210 and D11-2040.The second important finding is the candidates that block protein kinases signaling pathways or protein phosphatase signaling pathways,such as KP-372-1,17-AAG,and Mycograb;The third area pertains to candidates that target fungal virulence factors,like C7,²¹³Bi-18B7,¹⁸⁸Re-18B7 and so on.The fourth is the candidates that activate the host immune system,including PEV7 and β-(Man)₃-Fba-TT.Over all,these four areas demonstrate the exciting research progress on new targets of antifungal agents.

Key words: antifungal, target, compound, antibody, vaccine

CLC Number:

R978.5

HUANG Xin, LIU Ying, CHEN Si-min, AN Mao-mao, JIANG Yuan-ying. The research progress on new targets of antifungal candidates[J]. Chinese Journal of Mycology, 2015, 10(3): 175-181.

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