Abstract:

Objective To evaluate efficacy and safety of Meifute^® antifungal solution in treating tinea pedis cases from troops.Methods Generally,a single-session soak in Meifute^® antifungal solution for up to120-minute long was the suggested treatment of tinea pedis.As for some tinea pedis cases with hyperkeratosis or blisters,repeated treatment of one or two sessions at 14 day intervals might be recommended.Effect and safety evaluation was performed at week one (V1),week two (V2),and week four (V3) after initial treatment.Results Finally there were 206 cases of tinea pedis being enrolled into this study,including 104 cases of group Honour Guard (i.e.group H.G.)and 102 cases of group Armed Police (i.e.group A.P.).At week four (V3),overall effective rate was 95.6% (197/206),the cure rate was 78.2% (161/206),overall fungal clearance rate was 95.1%.Group H.G.had an effective rate of 96.1% (100/104) and a cure rate of 81.7% (85/104).Group A.P.got an effective rate of 95.1% (97/102) and a cure rate of 74.5% (76/102).There were only several cases of local side effects including mild pain (51/212) that could relieved once soak finished,and local mild edema (12/212)that self-subsided during 2 hours after soak.Follow-up of 6 months later revealed a recurrence rate of 8.97% (14/156).The recurrence rates of Group H.G.and Group A.P.were 3.06% (3/98) and 18.97% (11/58),respectively.The comprehensive satisfactory rate of patient reached up to 95.32%.Conclusion Meifute^® antifungal solution has showed good efficacy and is well tolerated in treating tinea pedis.It is especially recommended to be used in the patients who requiring a fastly and rapidly responsed therapeutic method to relieve their symptons and signs of tinea pedis within a short duration.

Key words: antifungal, tinea pedis, treatment