Abstract: This is a report of knee joint infection caused by Aspergillus flavus after anterior cruciate ligament reconstruction.A 26-year-old man was performed a surgery of cruciate ligament reconstruction with autologous tendon because of old cruciate ligament rupture.The symptoms of knee joint infection happened one week after the surgery and conventional anti-bacterial drugs showed ineffective.According to the history,clinical symptoms and the fungal culture positive with Aspergillus flavus,the patient was diagnosed as a fungal infection after surgery caused by Aspergillus flavus.After rinsing the joint cavity with 5% sodium bicarbonate solution and the use of amphotericin B (1% amphotericin B 20 mL,qd) infusion administration,combination use of voriconazole (200 mg,q12 h) oral for anti-fungal treatment,the patient's infection condition improved and was discharged after 28 days.

Key words: Aspergillus flavus, anterior cruciate ligament reconstruction, infection