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Chinese Journal of Mycology　2015, Vol. 10 　Issue (1): 22-24,5.

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In vitro susceptibility testing of domestic terbinafine hydrochloride against dermatophytes

TAN Xin1, PAN Wei-hua2, DENG Shu-wen2, GUO Yun1, LEI Wen-zhi2, ZHANG Chao2, ZHOU Zhao-jing2, FANG Wen-jie2, WEN Yi-yang3, SHEN Shuai-shuai3, ZHU Shuang2, YAO Zhi-rong4, ZHENG Jie5, DENG Dan-qi1, LIAO Wan-qing2   

  1. 1. Department of Dermatology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101;
    2. Shanghai Key Laboratory of Molecular Medical Mycology, Shanghai Changzheng Hospital, Shanghai 200003;
    3. Department of Dermatology, Shanghai Tongji Hospital, Shanghai 200065;
    4. Department of Dermatology, Shanghai Xinhua Hospital, Shanghai 200093;
    5. Department of Dermatology, Shanghai Ruijin Hospital, Shanghai 200025
  • Received:2014-10-21 Online:2015-02-28 Published:2015-02-28

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Abstract: Objectives To investigate the in vitro susceptibility testing of terbinafine against 138 strains of dermatophytes.Methods CLSI M38-A2 guideline was applied.The media containing the fungi in the concentration of(0.4-5)×104 CFU/mL were incubated at 30 for 7 days.The MIC endpoint was determined as the first concentration of antifungal agent that reached 100% inhibition of growth compared with the growth control.The MEC endpoint was determined as the first concentration of antifungal agent that reached 50% inhibition of growth compared with the growth control.Results The tested 138 strains of Dermatophytes were susceptible to terbinafine,MEC range:0.008-0.125 μg/mL,MIC 0.008-0.25μg/mL.There was no statistical differences between Beijia terbinafine and imported terbinafine(P>0.05).Conclusion Beija Terbinafine is active aganist Dermatophytes.It can be an effective choice in superficial mycosis treatment.

Key words: domestic terbinafine hydrochloride, dermatophytes, in vitro, antifungal susceptibility tests

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