The research developments in the therapy of allergic fungal asthma

Abstract

Abstract: Allergic fungal asthma is a chronic airway inflammatory disease induced by environmental exposure to airborne fungal allergens, which are ubiquitous in many indoor and outdoor environments. As a result of complex interactions among inflammatory cells, structural cells, and the intercellular matrix of the allergic lung, patients with allergic fungal asthma may experience a greater degree of airway wall remodeling and progressive, accumulated pulmonary dysfunction, along with the symptoms of wheeze, chest stufly and dyspnea, and have a serious impact on the job as well as personal life of the patients. However, the current standard asthma treatment options, such as glucocorticoids and antifungal agents, can hardly meet the requirements of this disease. Researches on the mechanism and therapeutics of allergic fungal asthma are gradually increased in the recent decades, and have made some progress, such as immunological therapy. In this review, we analyzed and summarized the Results of these researches.

Key words: fungal, allergic asthma, immunological therapy

CLC Number:

R562.2+5

YIN Qing-xin, SHI Dong-mei, LIAN Cui-hong, LIU Wei-da. The research developments in the therapy of allergic fungal asthma[J]. Chinese Journal of Mycology, 2014, 9(5): 299-302,292.

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