[1] Azie N, Neofytos D, Pfaller M,et al. The PATH (Prospective Antifungal Therapy) Alliance(R) registry and invasive fungal infections: update 2012
[J]. Diagn Microbiol Infect Dis,2012, 73(4):293-300.

[2] Ryan KJ, Ray CG.Sherris Medical Microbiology
[M]. 4th ed. New York: McGraw Hill,2004.

[3] Palmer GE.Vacuolar trafficking and Candida albicans pathogenesis
[J]. Commun Integr Biol, 2011, 4(2):240-242.

[4] Harvey WR. Physiology of V-ATPases
[J]. J Exp Biol,1992, 172:1-17.

[5] Kane PM.The where, when, and how of organelle acidification by the yeast vacuolar H⁺-ATPase
[J]. Microbiol Mol Biol Rev, 2006, 70(1):177-191.

[6] Kane PM. The long physiological reach of the yeast vacuolar H⁺-ATPase
[J]. J Bioenerg Biomembr,2007, 39(5-6):415-421.

[7] Martinez-Munoz GA, Kane P. Vacuolar and plasma membrane proton pumps collaborate to achieve cytosolic pH homeostasis in yeast
[J]. J Biol Chem,2008, 283(29):20309-20319.

[8] Martinez-Munoz GA, Pena A: In situ study of K⁺ transport into the vacuole of Saccharomyces cerevisiae
[J]. Yeast,2005, 22(9):689-704.

[9] Patenaude C, Zhang Y, Cormack B, et al.Essential role for vacuolar acidification in Candida albicans virulence
[J]. J Biol Chem, 2013, 288(36):26256-26264.

[10] Zhang YQ, Rao R. Beyond ergosterol: linking pH to antifungal mechanisms
[J]. Virulence, 2010, 1(6):551-554.

[11] Cowen LE, Zhang Y-Q, Gamarra S, et al.Requirement for ergosterol in V-ATPase function underlies antifungal activity of azole drugs
[J]. PLoS Pathogens,2010, 6(6):e1000939.

[12] Beyenbach KW.The V-type H⁺ ATPase: molecular structure and function, physiological roles and regulation
[J]. J Exp Biol,2006, 209(4):577-589.

[13] Pfaller MA, Diekema DJ.Epidemiology of invasive candidiasis: a persistent public health problem
[J]. Clin Microbiol Rev,2007, 20(1):133-163.

[14] Horn DL, Neofytos D, Anaissie EJ, et al. Epidemiology and outcomes of candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry
[J]. Clin Infect Dis, 2009, 48(12):1695-1703.

[15] Sudbery PE.Growth of Candida albicans hyphae
[J]. Nat Rev Microbiol 2011, 9(10):737-748.

[16] Naglik JR, Challacombe SJ, Hube B.Candida albicans secreted aspartyl proteinases in virulence and pathogenesis
[J]. Microbiol Mol Biol Rev 2003, 67(3):400-428.

[17] Karkowska-Kuleta J, Rapala-Kozik M, Kozik A.Fungi pathogenic to humans: molecular bases of virulence of Candida albicans,Cryptococcus neoformans and Aspergillus fumigatus
[J]. Acta Biochim Pol,2009, 56(2):211-224.

[18] Veses V, Richards A, Gow NA.Vacuoles and fungal biology
[J]. Curr Opin Microbiol,2008, 11(6):503-510.

[19] Bruckmann A, Kunkel W, Hartl A,et al.A phosphatidylinositol 3-kinase of Candida albicans influences adhesion, filamentous growth and virulence
[J]. Microbiology,2000, 146 (Pt 11):2755-2764.

[20] Eck R, Nguyen M, Gunther J, et al.The phosphatidylinositol 3-kinase Vps34p of the human pathogenic yeast Candida albicans is a multifunctional protein that interacts with the putative vacuolar H⁺-ATPase subunit Vma7p
[J]. Int J Med Microbiol,2005, 295(1):57-66.

[21] Poltermann S, Nguyen M, Gunther J, et al.The putative vacuolar ATPase subunit Vma7p of Candida albicans is involved in vacuole acidification, hyphal development and virulence
[J]. Microbiology,2005, 151(Pt 5):1645-1655.

[22] Tarsio M, Zheng H, Smardon AM, et al.Consequences of loss of Vph1 protein-containing vacuolar ATPases (V-ATPases) for overall cellular pH homeostasis
[J]. J Biol Chem,2011, 286(32):28089-28096.

[23] Bowman EJ, Siebers A, Altendorf K.Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells
[J]. Proc Natl Acad Sci U S A,1988, 85(21):7972-7976.

[24] Drose S, Bindseil KU, Bowman EJ, et al.Inhibitory effect of modified bafilomycins and concanamycins on P-and V-type adenosinetriphosphatases
[J]. Biochemistry,1993, 32(15):3902-3906.

[25] Menche D, Hassfeld J, Steinmetz H, et al.The first hydroxylated archazolid from the myxobacterium Cystobacter violaceus: isolation, structural elucidation and V-ATPase inhibition
[J]. J Antibiot (Tokyo), 2007, 60(5):328-331.

[26] Sasse F, Steinmetz H, Hofle G, et al.Archazolids, new cytotoxic macrolactones from Archangium gephyra (Myxobacteria). Production, isolation, physico-chemical and biological properties
[J]. J Antibiot (Tokyo), 2003, 56(6):520-525.

[27] Erickson KL, Beutler JA, Cardellina IJ, et al.Salicylihalamides A and B, Novel Cytotoxic Macrolides from the Marine Sponge Haliclona sp
[J]. J Org Chem,1997, 62(23):8188-8192.

[28] Kunze B, Jansen R, Sasse F, et al.Apicularens A and B, new cytostatic macrolides from Chondromyces species (myxobacteria): production, physico-chemical and biological properties
[J]. J Antibiot (Tokyo), 1998, 51(12):1075-1080.

[29] Boyd MR, Farina C, Belfiore P, et al.Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H⁺)-atpases
[J]. J Pharmacol Exp Ther,2001, 297(1):114-120.

[30] Kunze B, Steinmetz H, Hofle G, et al.Cruentaren, a new antifungal salicylate-type macrolide from Byssovorax cruenta (myxobacteria) with inhibitory effect on mitochondrial ATPase activity. Fermentation and biological properties
[J]. J Antibiot (Tokyo), 2006, 59(10):664-668.

[31] Gagliardi S,Nadler G,Consolandi E,et al.5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides:novel and selective inhibitors of the vacuolar H⁺-ATPase of osteoclasts with bone antiresorptive activity
[J].J Med Chem,1998,41(10):1568-1573.

[32] Dixon N, Pali T, Kee TP, et al.D.Interaction of spin-labeled inhibitors of the vacuolar H⁺-ATPase with the transmembrane Vo-sector
[J]. Biophys J 2008, 94(2):506-514.

[33] Chan CY, Prudom C, Raines SM, et al. Inhibitors of V-ATPase proton transport reveal uncoupling functions of tether linking cytosolic and membrane domains of V0 subunit a (Vph1p)
[J]. J Biol Chem,2012, 287(13):10236-10250.

[34] Hitchcock CA, Dickinson K, Brown SB, et al.Interaction of azole antifungal antibiotics with cytochrome P-450-dependent 14 alpha-sterol demethylase purified from Candida albicans
[J]. Biochem J,1990, 266(2):475-480.

[35] Maresova L, Muend S, Zhang YQ, et al.Membrane hyperpolarization drives cation influx and fungicidal activity of amiodarone
[J]. J Biol Chem,2009, 284(5):2795-2802.

[36] Monk BC, Kurtz MB, Marrinan JA, et al.Cloning and characterization of the plasma membrane H(+)-ATPase from Candida albicans
[J]. J Bacteriol,1991, 173(21):6826-6836.

[37] Billack B, Santoro M, Lau-Cam C: Growth inhibitory action of ebselen on fluconazole-resistant Candida albicans:role of the plasma membrane H⁺-ATPase
[J]. Microb Drug Resist,2009, 15(2):77-83.

[38] Ullah A, Lopes MI, Brul S, et al. Intracellular pH homeostasis in Candida glabrata in infection-associated conditions
[J]. Microbiology,2013, 159(Pt 4):803-813.

[39] Delloye-Bourgeois C, Jacquier A, Falk J, et al.Use of pHluorin to assess the dynamics of axon guidance receptors in cell culture and in the chick embryo
[J]. J Vis Exp,2014(83):e50883

[40] Martiniere A, Desbrosses G, Sentenac H, et al.Development and properties of genetically encoded pH sensors in plants
[J]. Front Plant Sci,2013,4:523.

[41] Hayek SR, Lee SA, Parra KJ,Advances in targeting the vacuolar proton-translocating ATPase (V-ATPase) for anti-fungal therapy
[J]. Frontiers in Pharmacology,2014,27(1):4.

[42] von Schwarzenberg K, Lajtos T, Simon L, et al.,V-ATPase inhibition overcomes trastuzumab resistance in breast cancer
[J]. Mol Oncol,2014, 8(1):9-19.

[43] Liu B, Fang M, Hu Y,et al. Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation
[J]. Autophagy,2013,10(3):416-430

[44] Lv X, Huang L, Chen W, et al. Molecular characterization and serological reactivity of a vacuolar ATP synthase subunit epsilon-like protein from Clonorchis sinensis
[J].Parasitol Res,2014,113(4):1545-1554.

[45] Shen H, He Z, Yan H,et al. The fronds tonoplast quantitative proteomic analysis in arsenic hyperaccumulator Pteris vittata L
[J]. J Proteomics,2014,13(6):46-57.