The treatment of 128 patients with invasive pulmonary aspergillosis

Abstract

Abstract:

Objective To improve understanding of invasive pulmonary asperginosis (IPA) and pay more attention to the classification of IPA so as to provide evidences for rational antifungal chemotherapy.Method The clinical features of 128 cases of IPA were analyzed retrospectively in West China Hospital of Sichuan University from January to December in 2011. This study focused on the risk factors, clinical manifestations, imaging findings, diagnosis and treatment methods. A total of 128 patients were enrolled.Results Seventeen patients were confirmed IPA by the positive culture results from the specimens collected by the bronchoscopy. One hundred and eleven patients were diagnosed as probable IPA. All patients had underlying diseases. All patients accepted antifungal treatment. The antifungal agents included voriconazole (86), amphotericin B liposome (1), itraconazole (12),micafindan (3), capofungin (15),amphotericin B (10) and voriconazole combined with caspofungin (1). Eighty-one patients (63.28%) were cured or improved. Twenty-four patients (18.75%) discharged from hospital due to poor economic conditions. Twenty-three patients (17.97%) died.Conclusion Most IPA patients had a variety of risk factors for infection. To reduce mortality rate of IPA, we should pay more attention to its stratification diagnosis, and choose appropriate antifungal agents.

Key words: invasive pulmonary aspergillosis, stratification diagnosis, treatment

CLC Number:

R563

FENG Xiu-juan, YE Hui, ZHONG Ce-jun, LIU Zhen-zhen, LV Xiao-ju. The treatment of 128 patients with invasive pulmonary aspergillosis[J]. Chinese Journal of Mycology, 2014, 9(3): 159-162,169.

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