Abstract:

Objective To investigate antifugal activity and the post-antifungal effect (PAFE) of Meifute antifungal solution against fungal induced tinea pedis.Methods We detected the minimum inhibitory concentration (MIC) of Meifute antifungal solution against fungal common induced tinea pedis using the United States CLSI M27-A3 and M38-2 scheme. Time-killing curve and post antifungal effects of Meifute antifungal solution against Candida albicans (ATCC90028) as the indicator fungal were measured.Result The MIC range, MIC₅₀ and MIC₉₀ of Meifute antifungal solution against 57 species were 1:40~1:160, 1:80 and 1:40 respectively. The ranges of the solution against Candida albicans and dermatophytes were 1:40~1:80 and 1:40~1:160. This antifungal solution has a strong antifungal effect. The degree and speed of the killing fungal were changed with the decrease of drug concentration. The PAFE of 0.5MIC, 1MIC and 2MIC were 0.85 h, 2.1 h and 3.59 h respectively, and the prolonged of PAFE was positively correlated to the antifungal solution concentration.Conclusion Meifute antifungal solution has a fast, sustained effect against Candida albicans and dermatophtes. Comparing with the effect on Candida albicans, the anigfungal solution have stronger antifungal effect on dermatophtes. The antifunal solution also have a long period of PAFE. These results showed that Meifute antifungal solution can be widely used to treat the superficial fungal infection of dermatophytes and Candida albicans.

Key words: minimal inhibitory concentration, time-kill curve, post antifungal effect