Abstract: Objective To study the clinical characteristics and outcome of patients with penicilliosis marneffei.Methods Retrospective review of 12 inpatients with penicilliosis marneffei in our hospital during ten years from January 2003 to October 2012.Results In addition to previously reported clinical manifestations including fever, rash, cough, dyspnea, serous effusion, hepatosplenomegaly, lymphadenopathy, digestive disorder, and osteolysis, we also observed pharyngalgia, edema of lower limbs, and vascular stenosis or occlusion as well. Laboratory examinations indicated 6 patients had abnormal routine urine examination, of whom 4 had elevated serum creatinine. Three out of four HIV positive patients were response to itraconazole combined with or without amphotericin B. Five out of eight HIV negative patients were response to voriconazole combined with or without other antifungal agents, and the other 3 were dead 2 to 11 days after the initiation of antifungal agents. Two of the 3 dead presented with ascites and dyspnea.Conclusions Pharynx, urinary system, peripheral circulation can also be involved in penicilliosis marneffei in addition to mononuclear phagocyte system.Penicillium marneffei is sensitive to voriconazole and itraconazole in vivo. Ascites and dyspnea possibly suggests poor prognosis. Early diagnosis and treatment of penicilliosis marneffei could improve the outcome.

Key words: Penicillium marneffei, retrospective review, clinical characteristic, prognosis