Abstract: Objective To screen the drugs which may have synergistic effects with fluconazole from 28 kinds of drugs including immunosuppressive agents, antilipemic agents, antidepressants, antibiotics and non-steroidal anti-inflammatory drugs.Methods 28 kinds of drugs within 5 main types were formulated intothe uniform concentrations of 100 μg/mL, then were dripped into the fungal suspensions of Candida albicans including fluconazole-resistant strains (100,103) and sensitive strains (sc5314,y0109), singly or together with fluconazole of low concentrations, respectively. Then the clarity of the fungal suspensions were observed respectively, the sensitive strains after 24 h, while the resistant strains after 48 h. "+" was noted for the completely clarified cases, while "-" for the turbid cases accordingly. The test was repeated three times simultaneously.Results Sertraline and other 6 kinds of drugs could inhibit the growth of all the Candida albicans under the concentration of 100 μg/mL singly, which had more significant effects when combined with fluconazole. Rifapentine and other 5 kinds of drugs could only inhibit the growth of the sensitive strains under that concentration singly, but were still effective on the resistant strains when combined with fluconazole of low concentrations.Conclusion Some drugs such as sertraline, rifapentine may have synergistic inhibition effect on Candida albicans with fluconazole.

Key words: Candida albicans, drugs, fluconazole, combined drug susceptibility testing