Abstract: Objective To observe the vitro inhibitive effect of lightyellow Sothora Root, Desefruit Pittany Poot-baik, Cacumen Platycladi, Radix Angelicae Sinensis and their mixture on the CBS standard strains of Malassezia.Methods Liquid medium including olive oil was used to test the sensitivity of Chinese herb to Malassezia.Results Minimum Inhibitive sensitivity (MIC) sorted from small to large were Dictamnine, Matrine, lightyellow Sothora Root, Cacumen Platycladi, Oxymatrine, Cacumen Platycladi+Radix Angelicae Sinensis (Immortals pills), Four Chinese herbal medicine mixture, Desefruit Pittany Poot-baik, Immortals pills+lightyellow Sothora Root, Immortals pills+Desefruit Pittany Poot-baik Root, Quercetin, Radix Angelicae Sinensis and Ferulic acid.Conclusion Four Chinese herbal medicine, their mixture and main active ingredients can inhibit Malassezia.

Key words: dandruff, Malassezia, Chinese herbal, Immortals pill, MIC