Abstract: Objective To observe the clinical efficacy in the treatment of tinea cruris by naftifine/ketoconazole cream.Methods One hundred and sixty patients with tinea versicolor were randomly divided into trial group and control group. Naftifine/ketoconazole cream were applied in the trial group. Miconazole nitrate cream were applied in the control group. Both were used in the morning and evening. Clinical and mycological therapeutic effects were evaluated in 2 weeks of treatment and in 3 weeks of drug withdrawal.Results The effective rates in the treatment group and control group were 92.5% and 76.25% respectively,there was significant difference between the two groups (P<0.05).Fungs clearance rate of the treatment group was 97.50% whereas control group was 87.5% at the end of 2 weeks treatment. There was significant difference between the two groups (P<0.05). The effective rates in the treatment group and control group were 96.25% and 75.00% respectively,there was significant difference between the two groups (P<0.05).Fungs clearance rate of the treatment group was 97.50% whereas control group was 85.00% at discontinued 3 weeks. There was significant difference between the two groups (P<0.05).No obvious adverse reaction.Conclusion Naftifine/ketoconazole cream in treatment of tinea cruris is effect and safe.

Key words: naftifine/ketoconazole cream, tinea cruris, treatment effect