Abstract: Objective The curative effect of terbinafine taken orally with different methods in the treatment of toenail onychomycosis was evaluated.Methods Based on group controlled, group A took oral terbinafine tablet 0.25 g/d for consecutive 12 weeks, group B took oral terbinafine tablet 0.25 g/d for the first 4 weeks, and then alternate-day dosing 0.25 g from the 5th week to the 16th week, recording and analyzing assessment at the 16th week and the 26th week respectively.Results 1 001 cases were validated.Group A got 512 cases which the clinical efficiency was 83.01%, 95.31% respectively; group B got 489 cases which the clinical efficiency was 81.12%, 93.86% respectively.Conclusion Two groups' corresponding period of observation efficiency by the chi-square test was difference with no statistically significant. In reducing dosage for 14 tablets can achieve similar efficacy, with it can improve the compliance of patient. Comparing the result of 26th week with the 16th week, curative effect further improved, it indicated that terbinafine tablet treatment to onychomycosis got significant after-effect.

Key words: onychomycosis, terbinafine, compliance