Abstract: Objective To evaluate the clinical effect of 5-ALA photodynamic therapy in treating patient of condyloma acuminatum (CA) with vulvovaginal candidiasis infections.Methods The 66 cases in treatment group were treated by photodynamic combined with antifungal therapy, while the 50 cases in control group by frozen combined with antifungal therapy.Results Complete response rate of treatment group was 92.4%, while that of control group was 78.0%. The difference was statistically significant (χ²=4.978, P=0.026); The cure rate of fungal infection of treatment group was 97.0%, while that of control group 86.0%. The difference was statistically significant (χ²=4.783, P=0.029). Patients were followed up for 6 months, the recurrence rate of condyloma of treatment group was 7.5%, the control group 24.0% (χ²=6.136, P=0.013). After 2 months of follow-up, the recurrence rate of fungi infection of treatment group was 4.5%, whlie the control group 16.0% (χ²=4.349, P=0.037).Conclusion 5-ALA photodynamic combined with antifungal is a safe and effective treatment of condyloma acuminatum (CA) with vulvovaginal candidiasis with low recurrence rate.

Key words: condyloma acuminatum, 5-ALA photodynamic, vulvovaginal candidiasis, fluconazole, clotrimazole