The research process of the synergistic antifungal effect of plant compositions

Abstract

Abstract: The incidence of systemic fungal infections have increased dramatically in recent years, but now clinically available antifungal drugs are limited, and the research and development of new drugs are difficult.So combination therapy is expected to become the ideal choice for antifungal therapy. Plant compositions can play a synergistic antifungal effect with the antifungal agents in the form of a monomer or mixture.Such research is more extensive and thorough in vitro, but further study on the antifungal effects in vivo, mechanisms and clinical trials is still needed. This review focuses on the antifungal synergism of plant compositions combined with antifungal agents, so as to provide a reference for the study of the novel antifungal drugs.

Key words: plant composition, synergism, antifungal effect, mechanisms

CLC Number:

R978.5

SHEN Ling, JIANG Yuan-ying, CAO Yong-bing. The research process of the synergistic antifungal effect of plant compositions[J]. Chinese Journal of Mycology, 2013, 8(1): 55-60.

References

[1] Mishra NN,Prasad T,Sharm a N,et al.Pathogenicity and drug resistance in Candida albicans and other yeast species. A review[J]. Acta Microbiol Immunol Hung, 2007,54 (3):201-235.
[2] Gafter-Gvili A,Vidal L,Goldberg E,et al.Treatment of invasive candidal infections:systematic review and meta-analysis[J].Mayo Clin Proc,2008,83(9):1011-1021.
[3] Montagna MT,De Giglio O,Napoli C,et al.Invasive fungal infections in patients with hematologic malignancies(aurora project):lights and shadows during 18-months surveillance[J].Int J Mol Sci,2012, 13(1):774-787.
[4] Lewis RE,Kontoyiannis DP.Rationale for combination antifungal therapy[J].Pharmacotheraoy,2001,21(8):149-164.
[5] Garcia-Gomes AS,Curvelo J,et al.Curcumin acts synergistically with fluconazole to sensitize a clinical isolate of Candida albicans showing a MDR phenoty[J]. Med Mycol,2012,50(1):26-32.
[6] Sharma M,Manoharlal R,Negi AS,et al.Synergistic anticandidal activityof pure polyphenol curcuminI in combinationwith azoles and polyenes generates reactive oxygen species leading toapoptosis[J].FEMS Yeast Res,2010,10(5):570-578.
[7] Faria NCG,Kim JH,Goncalves LAP,et al.Enhanced activity of antifungal drugs using natural phenolics against yeast strains of Candida and Cryptococcus[J].Lett Appl Microbiol,2011,52(5):506-513.
[8] Guo N,Ling GH, Liang XY,et al. In vitro synergy of pseudolaric acid B and ? uconazole against clinical isolates of Candida albicans[J].Mycoses,2010, 54(5):400-406.
[9] Sun L,Sun S,Cheng A,et al. In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans[J].Antimicrob Agent Ch,2009,53(4):1586-1591.
[10] Rukayadi Y,Lee K,Lee M,et al.Synergistic anticandidal activity of xanthorrhizol in combination with ketoconazole or amphotericinB[J].FEMS.Yeast Res,2009,9(8): 1302-1311.
[11] Pelletier SW.Alkaloids:Chemical and Biological Perspectives[M].New York :Jhon Wiley, 1983:26.
[12] Liang XY,Guo N,Wang LS,et al.Study on in vitro antifungal activity of dictiamnine against Candida albicans[J].Chinese Agricultural Science Bulletin,2009,25(16):21-24.
[13] 陶冉,潘扬.莲非酚性生物碱的化学及药理研究进展[J].现代中药研究与实践, 2008, 22( 3):63-64.
[14] 王慧敏.黄藤化学成分体外抗深部真菌活性研究.昆明:昆明医学院,2008.
[15] Li FX,Zhang H,Shan KR. In vitro study on the synergistic effect and mechanism of tetrandrine to fluconazole against hyphal form of Candida albicans[J].Chinese Journal of Zoonoses,2009,25(1):13-16.
[16] Li FX,Zhang H. In vitro study of the synergistic effect of tetrandrine and fluconazole against Candida albicans[J].Chin.J.Dermatol,2006,39(8):454-456.
[17] Wang Kl,Zhang H,Jiang HH,et al. In vitro study on tetrandrine as a synergist to fluconazole in murine model of vaginal candidiasis[J].Chinese Journal of Zoonoses,2007, 23 (5):474-478.
[18] Jin J,Guo N,Zhang J,et al.The synergy of honokiol and fluconazole against clinical isolates of azole-resistant Candida albicans[J].Lett Appl Microbiol, 2010,51(3):357-361.
[19] Endo EH,Garcia CDA,Ueda NT,et al.Potent antifungal activity of extracts and pure compound isolated from pomegranate peels and synergism with fluconazole against Candida albicans[J].Res Microbiol,2010,161(7):534-540.
[20] Ali I,Sharma P,Suri KA,et al. In vitro antifungal activities of amphotericin B in combination with acteoside, a phenylethanoid glycoside from Colebrookea oppositifolia[J].J Med Microbiol,2011,60(9):1326-1336.
[21] Khan MSA,Malik A,Ahmad I.Anti-candidal activity of essential oils alone and in combination with amphotericin B or fluconazole Against multi-drug resistant isolates of Candida albicans[J]. Med Mycol,2011,50(1):33-42.
[22] Guo N,Wu XP,Yu L,et al. In vitro and in vivo interactions between fluconazole and allicin against clinical isolates of fluconazole-resistant Candida albicans determined by alternative methods[J].FEMS Immunol Med Mic,2010,58(2):193-201.
[23] Khodavandi A,Alizadeh F,Aala F,et al. In vitro investigation of antifungal activity of allicin alone and in combination with azoles against Candida species[J].Mycopathologia,2010,169 (4):287-295.
[24] Guo X L,Leng P,Yang Y,et al.Plagiochin E, a botanic-derived phenolic compound, reverses fungal resistance to fluconazole relating to the efflux pump[J].J Appl Microbiol,2008,104 (3):831-838.
[25] Johann S,Sá NP, Limaet LARS,et al.Antifungal activity of schinol and a new biphenyl compound isolated from Schinus terebinthifolius against the pathogenic fungus Paracoccidioides brasiliensis[J].Annals of Clinical Microbiology and Antimicrobials,2010,9(30):1-6.
[26] Quan H,Cao YY,Xu Z,et al.Potent in vitro synergism of fluconazole and berberine chloride against clinical isolates of Candida albicans resistant to fluconazole[J].Antimicrob Agents Chemother, 2006,50(3):1096-1099.
[27] Huang S,Cao Y Y,Dai B D,et al. In vitro synergism of fluconazole and baicalein against clinical isolates of Candida albicans resistant to fluconazole[J].Biol Pharm Bull, 2008,31(12):2234-2236.
[28] Saada A, Fadlia M, Bouaziz M,et al.Anticandidal activity of the essential oils of Thymus maroccanus and Thymus broussonetii and their synergism with amphotericin B and fluconazole[J].Phytomedicine,2010,17(13):1057-1060.
[29] Amber K, Aijaz A, Immaculata X,et al.Anticandidal effect of Ocimum sanctum essential oil and its synergy with fluconazole and ketoconazole[J]. Phytomedicine,2010,17(12):921-925.
[30] Silvaa F,Ferreiraa S,Duartea A,et al.Antifungal activity of Coriandrum sativum essential oil, its mode of action against Candida species and potential synergism with amphotericin B[J].Phytomedicine,2011,19(1):42-47.
[31] Rosato A, Vitali C,Gallo D, et al.The inhibition of Candida species by selected essential oils and their synergism with amphotericin B[J].Phytomedicine.2008,15(1):635-638.
[32] Rosato A,Vitali C,Piarulli M,et al. In vitro synergic efficacy of the combination of Nystatin with the essential oils of Origanum vulgare and Pelargonium graveolens against some Candida species[J].Phytomedicine,2009,16(10):972-975.
[33] Li XQ,Luo ZC,Li WZ.Study on anti-candidal activity of the essential oil from Rosa rugosa in vitro and the difference between Macro and Micro dilution methods[J].Chi J Derm Venereol,2006,20(6):321-323.
[34] Pyun MS,Shin S.Antifungal effects of the volatile oils from Allium plants against Trichophyton species and synergism of the oils with ketoconazole[J].Phytomedicine,2006,13(6):394-400.
[35] 张石群,林辉,苗琦,等.覆盆子提取物联合唑类药物抗真菌活性研究[J].中国真菌学杂志,2012,7(1):4-7.
[36] Sun LM,Cheng AX,Wu XZ,et al.Synergistic mechanisms of retigeric acid B and azoles against Candida albicans[J]. J Appl Microbiol,2009,108(1):341-348.
[37] Zhang H,Gao AL,Li F,et al.Mechanism of action of tetrandrine,a natural inhibitor of Candida albicans drug efflux pumps[J].The Pharmaceutical Society of Japan,2009,129(5):623-630.