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Chinese Journal of Mycology 2012, Vol. 7  Issue (1): 55-58.

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Advances in research on mechanisms for drug resistance of Candida krusei

QIAO Zu-sha, FENG Wen-li   

  1. Department of Dermatovenereology, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2011-09-27 Online:2012-02-28 Published:2012-02-28

Abstract: Invasive infections of Candida krusei increased in recent years contributed to the resistance to fuconazole.The mechanism of resistance in C.krusei may be a variety of drug-resistant possibilities including changed structure of cytochrome P450 sterol 14-demethylase in fungal cell,overexpression of efflux pumps,and reduced intracellular drug accumulation.

Key words: Candida krusei, antifungal drug, drug resistant, molecular mechanisms

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