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Chinese Journal of Mycology　2012, Vol. 7 　Issue (1): 33-36.

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A case report of cutaneous infection by Rhizopus microsporus variants with acute promyelocytic leukemia

WANG Lu-Xia1, LAI Huang-Wen2, SHI Ling-Bo3, LIANG Yu-Hen4, LI Li5, WU Xiao-Li2, FU Jie6, LIU Hai-Ying6   

  1. 1. Department of clinical laboratory, Guangzhou General Hospital of PLA Guangzhou Command, Guangzhou 510010;
    2. Department of Medical Laboratory, Guangzhou General Hospital of PLA Guangzhou Command, Guangzhou 510010;
    3. Department of clinical laboratory, Clifford Hospital, Guangzhou University of Chinese Medicine, Guangzhou 511495;
    4. Department of Dermatology, The Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120;
    5. Department of hematology, Guangzhou General Hospital of PLA Guangzhou Command, Guangzhou 510010;
    6. Clinical laboratory, Guangzhou women and children＇s medical center, Guangzhou 510180
  • Received:2011-11-02 Online:2012-02-28 Published:2012-02-28

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Abstract: A case of cutaneous mucormycosis caused by Rhizopus microsporus variants was reported.An 30-year-old female with immunodeficiency and granulocytopenia after chemotherapy for acute promyelocytic leukemia was sufferred form fever and mucosa edema in the right submaxillary area,which gradually involved the right neck and right mandible.Necrotic tissue smear showed thick and right angle hyphae,which was further identified as Rhizopus microsporus variants by mycological examination and DNA sequencing.After intravenous amphothericin B and itraconazole with surgical debridement,the body temperature returned to normal.The lesion improved after two weeks and healed after four weeks without relapse within two years.

Key words: acute promyelocytic leukemia, Rhizopus microsporus variants, cutaneous mucormycosis

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