Abstract: Objective To evaluate the diagnostic value of serum IL-27 on children with mycosis intestinalis.Methods The serum level of IL-27 and PCT of 89 children with mycosis intestinalis,61 viralgastroenteritis and 41 healthy volunteers were detected by ELISA.The association between IL-27 and white blood cell count and PCT was analysed.The diagnostic value of IL-27 on children with mycosis intestinalis was evaluated by receiver operating characteristics(ROC) curve analysis.Results The level of serum IL-27 was significantly increased in children with mycosis intestinalis than that of viral intestinalis group and healthy control group(P<0.01).The level of serum IL-27 positive correlated with PCT,was observed in children with mycosis intestinalis.Area under cure(AUC) confirmed by ROC analysis was 0.82(95% Confidence interval(CI):0.63-0.89) for IL-27.At the best cut-off value of 0.82 pg/ml,the diagnostic sensitivity and specificity of IL-27 are 0.75 and 0.79 respectively.Conclusions Serum IL-27 has high diagnostic performance for children with mycosis intestinalis,which should be an early biomarker for children with mycosis intestinalis.

Key words: mycosis intestinalis, Interleukin-27, diagnosis