A role of MAPK pathway in the pathogenic mechanism of Cryptcococcus neoformans

Abstract

Abstract: Cryptococcus neoformans/Cryptococcus gatti is a dimorphic basidiomycetous pathogenic fungus.Cryptococcus meningitis is the most common cryptococcosis, causing high mortality and morbidity. Efficient communication with host's environment is crucial to survival of Cryptococcus neoformans. Cryptococcus neoformans has developed complex signaling systems to sense and reply to their environment, to control proliferation and virulence. Including HOG-MAPK (high osmolarity glycerol mitogen activated protein kinase signaling transduction pathway), PKC-MAPK (protein kinase C mitogen activated protein kinase signaling transduction pathway), and Ste12-MAPK (sterile12 transcriptors mitogen activated protein kinase signaling transduction pathway),MAPK (mitogen-activated protein kinase)signaling pathway is one of the most important signaling pathways. Investigation on components of these MAPK signaling pathways is not only useful to discover their role in Crytococcosis, but also helpful to explore new possible antifungal drug targets.

Key words: MAPK, signaling pathway, Cryptococcus neoformans, Crytococcosis

CLC Number:

R379.5

HUANG You-ming, ZHU Hong-mei, WEN Hai. A role of MAPK pathway in the pathogenic mechanism of Cryptcococcus neoformans[J]. Chinese Journal of Mycology, 2012, (5): 304-308.

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