Abstract: Objective To investigate the therapeutic effects of lactobacillus vaginal capsules for adjustment of vaginal microenvironment in the treatment of pregnancy recurrent valvovaginal candidiasis.Methods Total 266 outpatients of pregnancy recurrent valvovaginal candidiasis from December 2009 to December 2011 in our hospital were divided into experimental group and control group by random principle. The patients of experimental group took lactobacillus vaginal capsules and the antifungal treatment by clotrimazole suppository combined with traditional chinese medicine; the patients of control group took only clotrimazole suppository combined with traditional chinese medicine. The clinical effects, the rates of long-term self-healing,the long-term recurrence and the recurrence rates during delivery after the end of treatment were observed.Results The short term cure rates of the two groups were similar (P>0.05), however, there was statistic differences in the rates of long-term self-healing, the long-term recurrence rates and the recurrence rates during delivery after the application of lactobacillus vaginal capsules on experimental group (P<0.05). The rate of long-term self-healing was 28.57% in experimental group,which was significantly higher than that in control group and the long-term recurrence rate was 11.03% in experimental group, which was significantly lower than that in control group (26.92%) and the recurrence rate during delivery after treatment was 10.29% in experimental group, which was significantly lower than that in control group (29.23%).Conclusion Adjustment of vaginal microenvironment with application lactobacillus vaginal capsules and the antifungal treatment by clotrimazole suppository combined with traditional chinese medicine have good therapeutic effects on the treatment of pregnancy recurrent valvovaginal candidiasis, with high self-healing rate, low rate of recurrence and little side reaction.

Key words: living preparation of lactobacillus, vulvovaginal candidiasis, recurrent, microenvironment, pregnancy