Pathogenic hydrolases of Candida albicans

Abstract

Abstract: Candida albicans is an important pathogenic fungus for human. Its pathogenicity is associated with various factors. Hydrolases belong to one of the most important virulence factors of C. albicans, which play a key role in fugal invasion. Pathogenic hydrolases of C. albicans comprise secreted aspartyl proteinases, phospholipases and lipases, which mediate phenotype conversion, adhesion to host tissue and intervention with host immune system.With these hydrolases,C. albicans is facilitated to invade host tissue and escaped from host anti-fungal immunity. Here we reviewed the updated studies in the biological and pathogenicity of C. albicans virulent hydrolases.

Key words: Candida albicans, secreted aspartyl proteinase, phospholipase, lipase

CLC Number:

R519.3

MA Hu, CUI Fan, LIN Zhao-chun. Pathogenic hydrolases of Candida albicans[J]. Chinese Journal of Mycology, 2012, (4): 247-251.

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