Abstract: A case of facial subcutaneous sporotrichsis caused by a multidrug-resistant Sporothrix schenckii strain was reported. A 61-year-old man had a history of facial plaques for 2 years. Whereas the patient had been treated with itraconazole, terbinafine and fluconazole successively for 16 months, the therapy was failed. According to mycological results of skin lesion, a diagnosis of sporotrichosis was made. However, the isolate of this case was not sensitive to itraconazole, terbinafine and fluconazole in both hyphae phase and yeast phase. The case had been cured by oral 10% potassium iodide for 3 months.

Key words: Sporothrix schenckii, sporotrichosis, multi-drug resistant, 10% potassium iodide