Progression on the research of two-component signal transduction system in fungus and its inhibitors

Abstract

Abstract: Two-component signal transduction system,which plays an important role in cell metabolism,virulence and pathogenicity,has been found in most lower eukaryotes,prokaryotes and some plants,yet not in human cells.Well-understanding of the mechanism may be helpful for inhibitor designing,which has antifungal effect without damage to host cell.Recent literatures about two-component signal transduction system in fungi and potential inhibitors are reviewed.

Key words: fungus, two-component signal transduction, inhibition, drug targets

CLC Number:

R379

XU Xi-guang, ZHANG Zi-ping, CHENG Bo. Progression on the research of two-component signal transduction system in fungus and its inhibitors[J]. Chinese Journal of Mycology, 2011, 6(6): 370-372380.

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