Fungal rhinosinusitis casused by Scedosporium apiospermum:a case report and literature review

Abstract

Abstract: Objective To report a case of rhinosinusitis caused by Scedosporium apiospermum and to study the laboratory methods and the in vitro sensitivity to five kinds of antifungal drugs.Methods The mass cut off from the rhinosinusitis patient was prepared for microscopy(10% KOH and Gram dying),fungal culture(SDA) and molecular biological identification.In vitro drug sensitivity was determined by E-test.Results The isolate was identified as Scedosporium apiospermum.The MICs of five kinds of drugs were 0.064 μg/mL(voriconazole),1.500 μg/mL(caspofungin),16.000 μg/mL(fluconazole),>32 μg/mL(amphotericin B) and >32.000 μg/mL(5-flucytosine) respectively.Conclusions Fungal rhinosinusitis caused by Scedosporium apiospermum is rare in China and easily confused with tumor.Laboratory examination is important for correct diagnosis.Nasal endoscopic operation with antifungal treatment based on drug resistance test has therapeutic effect.

Key words: fungal rhinosinusitis, Scedosporium apiospermum, antifungal agents

CLC Number:

R756.6

WANG Yan-ling, SUN Ji-mei, ZHOU Xiu-zhen, ZHANG Zhi-jie, ZHENG Wei, CUI Bing, LIU yong. Fungal rhinosinusitis casused by Scedosporium apiospermum:a case report and literature review[J]. Chinese Journal of Mycology, 2011, 6(5): 285-289.

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