Abstract: Objective To compare the susceptibilities of Candida albicans cultured with ginseng stems and leaves saponins,Panax Pseudoginseng,fluconazole and itraconazole.Methods Susceptibilities of 60 candida isolates cultured with fluconazole,itraconazole,ginseng stems and leaves saponins and Panax Pseudoginseng was determined by M27-A Microdilution Method based on CLSI.Results The MIC₅₀ and MIC₉₀ of Candida albicans to fluconazole,itraconazole,ginseng stems and leaves saponins and Panax Pseudoginseng were 0.25 mg/L,0.25 mg/L,7.812 mg/L,15.625 mg/L(MIC₅₀),and 64 mg/L,16 mg/L,250 mg/L,250 mg/L(MIC₉₀),respectively.Ten of the total 60 isolates showed cross-resistances to itraconazole,ginseng stems and leaves saponins and Panax Pseudoginseng.Conclusions Ginseng stems and leaves saponins and Panax Pseudoginseng have similar antifungal effects on Candida albicans.CLSI-M27-A could be used to evaluate the anti-candida activity to the components of medicinal plant as a standard method.

Key words: Candida, microbial susceptibility tests, fluconazole, itraconazole, ginseng stems and leaves saponins, Panax Pseudoginseng