Abstract: Objective To study the antifungal susceptibility of oral Candida from drug abusers and to provide references for clinical treatment of candidosis.Methods Susceptibilities to four common antifungal drugs (fluconazole,ketoconazole,5-flurocytosine and amphotericine B) were determined in 75 isolates of oral Candida by broth microdilution antifungal susceptibility test recommended by CLSI.Results The resistant rates of 75 isolates of oral Candida from drug abusers to Amb,5-FC,FCZ,and KETO were 0%, 4%, 8%, and 13.3%, respectively (P<0.01).The crosswise resistant rates of these strains to FCZ and KETO were 8%.The resistant rate and crosswise resistant rate of non-Candida albicans to FCZ and KETO were higher than those of Candida albicans (P<0.05).Conclusions Oral Candida species from drug abusers are resistant to FCZ,KETO and 5-FC in nature,but crosswisely resistant to FCZ and KETO.The resistant and crosswise resistant rates of non-Candida albicans to FCZ and KETO are higher than those of Candida albicans.

Key words: Candida, antifungal susceptibility, drug abusers