Diagnostic value of Chinese assay of (1,3)-β-D-glucan in invasive fungal infections

Abstract

Abstract: Objective To evaluate the diagnostic value of Chinese assay of (1,3)-β-D-glucan in invasive fungal infections (IFI) and compare with Japenese assay.Methods A retrospective study was performed on 203 patients at risk of IFI (totally 342 sanmples) in our hospital from April,2008 to May,2009.Paired-sample t test was analyzed in 100 samples which were detected by both Chinese and Japanese assay.Sensitivity,specificity,positive predictive value (PPV) and negative predictive value (NPV) were calculated under different criterion,which was compared by McNemar paired χ² test.Results The significance values of t test between the two assays were 0.235 for IFI samples and 0.076 for non-IFI samples,respectively.For Chinese assay ,the sensitivity (78.3%,56.5%,25.0%,25.0%) and specificity (67.2%,85.0%,64.9%,87.7%) were obtained by single cutoff values or double cutoff values of 20 pg/mL,50 pg/mL respectively.Conclusions There is no statistical significance between Chinese and Japanese assays.The specificity with single cutoff value of 50 pg/mL was significantly elevated without evident influence on sensitivity compared with that with 20 pg/mL.The NPV and specificity were elevated with double cutoff values.

Key words: (1,3)-β-D-glucan, diagnosis, Chinese assay, Japanese assay

CLC Number:

R446.53

GAO Lu-juan, YU Jin, WANG Xiao-hong, WAN Zhe, LI Ruo-yu. Diagnostic value of Chinese assay of (1,3)-β-D-glucan in invasive fungal infections[J]. Chinese Journal of Mycology, 2010, 5(5): 277-281.

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