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Chinese Journal of Mycology 2010, Vol. 5  Issue (3): 141-143.

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Combined caspofungin and TMP-SMX treatment for PCP in AIDS patients

JIANG Xue-yan1, ZHANG Ren-fang1, ZHENG Yu-fang1, LIU Li1, SHEN Yin-zhong1, LU Hong-zhou1,2   

  1. 1. Department of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China;
    2. Department of Infectious Disease, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Received:2009-09-25 Online:2010-06-28 Published:2010-06-28

Abstract: Objective To observe the efficacy of caspofungin combined with trimethoprim sulfamethoxazole (TMP-SMX) in the treatment of pneumocystis pneumonia (PCP) in AIDS patients.Methods Clinical feature,diagnosis and treatment procedure of nine PCP with AIDS patients were analyzed retrospectively.Results All of nine patients clinically diagnosed as PCP were administered with caspofungin and TMP-SMX.Eight patients acquired satisfied effects except one old with chronic obstructive pulmonary disease died.Conclusions Combined therapy of caspofungin and TMP-SMX has good efficacy for the treatment of PCP in AIDS patients.

Key words: caspofungin, trimethoprim sulfamethoxazole (TMP-SMX), acquired immune deficiency syndrome, pneumocystis pneumonia (PCP)

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