Abstract: To report a case of Graves ophthalmopathy with fungus infection in cornea.An 31 year old woman was suffered from hyperthyroidism with infiltrating exophthalmos,which led to reduced visual acuity and macular edema.Antithyroid drugs (ATD) were firstty administered,but hyperthyroidism did not improve after one-month treatment.High Dose Methylprednisolone and local injection of triamcinolone acetonide were then applied for three months while scanttered ulcer of cornea and light perception missing appeared.One week later,the patient was suffered from high fever,the highest of 39.5℃,fluctuating from 36.7℃ to 37.3℃ after anti-bacteria treatments.Hyphae and spores were found in the corneal secretion.Temperature and visual acuity recovered and the area of corneal ulcer reduced after combinition therapy of ATD,nutrition support and antifungal measures.

Key words: Graves ophthalmopathy, fungal, corneal ulcer