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中国真菌学杂志 2023, Vol. 18  Issue (2): 123-129.

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2002—2022亚洲地区奥默柯达感染回顾性分析

朱信霖1, 李晨2, 扈东营1, 陈显振1, 姜伟伟1, 刘伊诺1, 陈天杨1, 陈天成1, 廖万清1, 刘晓刚1, 潘炜华1   

  1. 1. 海军军医大学第二附属医院皮肤科, 上海市医学真菌分子生物学重点实验室, 上海 200003;
    2. 海军军医大学第一附属医院脑血管病中心, 上海 200433
  • 收稿日期:2022-04-14 出版日期:2023-04-28 发布日期:2023-05-26
  • 通讯作者: 潘炜华,E-mail:panweihua9@sina.com;刘晓刚,E-mail:liuxiaogang67@126.com E-mail:panweihua9@sina.com;liuxiaogang67@126.com
  • 作者简介:朱信霖,男(汉族),博士研究生在读.E-mail:6299397@qq.com;李晨,女(汉族),本科,护师.E-mail:1535684139@qq.com
  • 基金资助:
    国家自然科学基金重点国际(地区)合作研究项目(81720108026);国家自然科学基金面上项目(82072257);国家自然科学基金青年项目(82002124)

Retrospective analysis of Kodamaea ohmeri infection in Asia from 2002 to 2022

ZHU Xinlin1, LI Chen2, HU Dongying1, CHEN Xianzhen1, JIANG Weiwei1, LIU Yinuo1, CHEN Tianyang1, CHEN Tiancheng1, LIAO Wanqing1, LIU Xiaogang1, PAN Weihua1   

  1. 1. Department of Dermatology, Second Affiliated Hospital of Naval Medical University, Shanghai Key Laboratory of Molecular Medical Mycology, Shanghai 200003, CHina;
    2. Neurovascular Center, First Affiliated Hospital of Naval Medical University, Shanghai 200433, China
  • Received:2022-04-14 Online:2023-04-28 Published:2023-05-26

摘要: 目的 分析亚洲地区奥默柯达感染的流行病学和临床特征,为提高奥默柯达感染的诊治水平提供科学依据。方法 采用文献回顾和荟萃分析的方法,对亚洲地区已报道的奥默柯达感染患者的国籍、性别、年龄、危险因素、发病部位、临床表现、诊疗方法及预后等流行病学和临床特征进行回顾性分析。结果 奥默柯达感染在免疫功能正常和免疫功能缺陷患者中均可发生,发病患者男女比例为1.59∶1,尤其好发于早产儿及中年患者,血液系统为最常受累部位。超半数患者伴有免疫抑制的基础疾病或危险因素,早期缺乏特异性的临床表现,多数患者可出现发热症状。奥默柯达的临床确诊主要依赖培养。患者预后较差,死亡率高。结论 近年来奥默柯达感染的发病率呈上升趋势,诊断主要依赖于真菌培养。加强奥默柯达菌株的体外药敏监测和流行病学研究,对提高奥默柯达感染的临床诊治水平具有重要意义。

关键词: 奥默柯达, 流行病学, 临床特征

Abstract: Objective To analyze epidemiological trends and clinical characteristics of cases caused by Kodamaea ohmeri in Asia, and to provide a scientific basis for improving the clinical diagnosis and treatment of K. ohmeri infections. Methods Using the methods of literature review and meta-analysis to analyze retrospectively the information of patient’s nationality, sex and aged composition, risk factors, onset organs, clinical manifestations, therapeutic methods and prognosis of K. ohmeri. Results K. ohmeri infections could occur in both immunocompetent and immunocompromised person. The gender ratio of the infection host was 1.59:1, predominantly in premature neonate and middle aged people, and the blood system was the most commonly affected site. More than half of the patients had immunodeficiency diseases or other risk factors, and there were no early specific symptom with chief complaints of fever. Diagnosis of K. ohmeri infections mainly relied on culture. The patients had a poor prognosis, with high mortality. Conclusion The incidence of K. ohmeri infections has increased recently and the diagnosis mainly depends on culture. Strengthening the in vitro antifungal susceptibility monitoring and the studying of epidemiology for K. ohmeri are significant to improve the diagnosis and prognosis of K. ohmeri infections.

Key words: Kodamaea ohmeri, epidemiology, clinical characteristics

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