胶红酵母菌感染流行现状的回顾性分析

摘要/Abstract

摘要： 目的分析胶红酵母菌感染的流行病学和临床特征,为提高胶红酵母菌感染的诊疗水平提供科学依据。方法采用文献回顾和荟萃分析的方法,对全球范围内近二十年报道的胶红酵母菌感染病例的国籍、性别、年龄、危险因素、发病部位、诊疗方法及预后等进行回顾性分析。结果经筛选,共纳入相关文献45篇,包含胶红酵母菌感染确诊患者60例。胶红酵母菌感染最常见于欧洲地区,发病患者男女比例为1.68∶1,尤其好发于0~10岁儿童及40~50岁的患者,血液系统为最常受累部位。多数患者伴有基础疾病或外伤、手术等危险因素,早期缺乏特异性的临床表现,多数患者表现为发热症状。胶红酵母菌感染的临床确诊主要依赖培养。除预后不详患者外,死亡率高达12.5%。结论近年来胶红酵母菌感染的发病率在全球范围呈上升趋势,血液系统为最常受累部位,诊断主要依赖于真菌培养。加强胶红酵母菌菌株的体外药敏监测及流行病学研究,有利于提高胶红酵母菌感染的临床诊疗水平。

关键词: 胶红酵母菌, 流行病学, 临床特征

Abstract: Objective To analyze epidemiological and clinical characteristics of infections caused by Rhodotorula mucilaginosa, and to provide a scientific basis for improving the clinical diagnosis and treatment of R. mucilaginosa infections. Methods Using the methods of literature review and meta-analysis to analyze retrospectively the information of patient's nationality, sex and aged composition, risk factors, onset organs, diagnostic and therapeutic methods and prognosis of R. mucilaginosa worldwide in the past two decades. Results A total of 45 related literatures were included, including 60 cases of patients infected by R. mucilaginosa. R. mucilaginosa infections was most common in Europe. The gender ratio of the infection host was 1.68:1, predominantly in people aged 0-10 years and 40-50 years, and the blood system was the most commonly affected site. Most patients had underline diseases or other risk factors such as trauma and surgery, and there was no early specific symptom with chief complaints of fever. Diagnosis of R. mucilaginosa infections mainly relied on culture. The mortality rate was as high as 12.5%, except in patients with unknown prognosis. Conclusion The incidence of R. mucilaginosa infections has increased recently worldwide. The most commonly affected site was blood system, and the diagnosis mainly depends on culture. Strengthening the in vitro antifungal susceptibility monitoring and the studying of epidemiology for R. mucilaginosa are benefical to improve the clinical diagnosis and prognosis of R. mucilaginosa infections.

Key words: Rhodotorula mucilaginosa, epidemiology, clinical characteristics

中图分类号:

R519.8

朱信霖, 李晨, 扈东营, 陈显振, 陈天杨, 陈天成, 廖万清, 陈敏, 潘炜华. 胶红酵母菌感染流行现状的回顾性分析[J]. 中国真菌学杂志, 2023, 18(1): 24-32.

ZHU Xinlin, LI Chen, HU Dongying, CHEN Xianzhen, CHEN Tianyang, CHEN Tiancheng, LIAO Wanqing, CHEN Min, PAN Weihua. A retrospective analysis of cases caused by Rhodotorula mucilaginosa[J]. Chinese Journal of Mycology, 2023, 18(1): 24-32.

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