转录因子在白念珠菌自噬过程中的调控机制

摘要/Abstract

摘要： 自噬是细胞内主要的降解途径之一，是一个高度保守的动态过程，对于真核细胞的适应、分化和发育具有重要作用，自噬在白念珠菌中影响着菌株的代谢和毒力，可增强菌体的存活能力。自噬调节失衡与多种疾病相关，需在多个水平受到精确调控，以维持细胞内稳态平衡。白念珠菌的毒力致病与自噬过程中关键转录因子的异常表达调控密切相关。该文主要概括了自噬的主要阶段及相关机制，并说明自噬过程中主要转录因子可能的作用机制，以了解白念珠菌自噬中的转录调控机制，为白念珠菌未来的治疗提供新的方向。

关键词: 白念珠菌, 细胞自噬, 自噬相关基因, 转录因子

中图分类号:

R379.4

张露文, 冯文莉. 转录因子在白念珠菌自噬过程中的调控机制[J]. 中国真菌学杂志, 2022, 17(2): 158-162.

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