烟曲霉肺部感染的免疫逃逸作用机制研究进展

摘要/Abstract

摘要： 侵袭性曲霉感染是免疫低下患者死亡重要原因。烟曲霉作为曲霉感染中最为常见的一类是重症患者中常见的肺部真菌感染，具有侵袭性和难治性。其通过吸入宿主体内，通过分泌的蛋白水解酶等定植于肺部。为了对抗宿主体内的保护性免疫反应并持续性生长繁殖，烟曲霉已经开发出了许多复杂且有效的免疫逃逸策略，包括黏附/定植、适应内环境压力、改变营养摄取、逃避宿主补体监视和下调宿主抗真菌反应等多种机制。了解真菌病原体与宿主间复杂的免疫串扰将是研究真菌感染发生机制和治疗标靶的核心内容，为从抗宿主免疫层面探讨烟曲霉治疗方法提供新思路。该文对近年来有关烟曲霉肺部感染的免疫逃逸机制研究进展作一综述。

关键词: 烟曲霉, 肺部感染, 免疫反应, 免疫逃逸

中图分类号:

R379.6

严唯, 林时辉, 幸宇, 徐昉. 烟曲霉肺部感染的免疫逃逸作用机制研究进展[J]. 中国真菌学杂志, 2021, 16(3): 196-201.

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