白念珠菌生物膜滞留菌与转录因子GCN4的研究进展

摘要/Abstract

摘要：

白念珠菌是一种常见的条件致病性真菌。由于抗真菌药物的广泛使用及体内植入器材表面生物膜的形成，造成其耐药现象的逐年增加。目前白念珠菌生物膜的耐药机制主要有靶酶基因的突变、外排泵基因的高表达、生物膜滞留菌的形成等，其中滞留菌的作用越来越突出。饥饿状态下，不仅滞留菌的形成比例增加，转录因子GCN4表达也增加，滞留菌的形成与转录因子GCN4可能存在一定的相关性。本文将综述白念珠菌滞留菌及转录因子GCN4的相关内容。

关键词: 白念珠菌, 滞留菌, 生物膜, 耐药性, GCN4

中图分类号:

R379.4

王佳佳, 冯文莉. 白念珠菌生物膜滞留菌与转录因子GCN4的研究进展[J]. 中国真菌学杂志, 2019, 14(2): 116-119.

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