子宫颈感染孢子丝菌1例

中国真菌学杂志　 2019, Vol. 14 　Issue (1): 47-49.

子宫颈感染孢子丝菌1例

张一男¹, 刘晓娜², 杨晶¹, 刘玥姣¹, 石铭¹, 薛文成¹

1. 大连九洲世纪医院检验科, 大连市 116400;
2. 大连九洲世纪医院妇科, 大连市 116400

收稿日期:2018-09-05 出版日期:2019-02-28 发布日期:2019-02-28
通讯作者: 薛文成,E-mail:13309884078@189.cn E-mail:13309884078@189.cn
作者简介:张一男:女(汉族),大学本科,技师.E-mail:1124215712@qq.com

A case of sporotrichosis in the uterine cervix

ZHANG Yin-an¹, LIU Xiao-na², YANG Jing¹, LIU Yue-jiao¹, SHI Ming¹, XUE Wen-cheng¹

1. Department of Laboratory Medicine, Dalian Jiuzhou Century Hospital, Dalian 116400, China;
2. Gynecology Department, Dalian Jiuzhou Century Hospital, Dalian 116400, China

Received:2018-09-05 Online:2019-02-28 Published:2019-02-28

摘要/Abstract

摘要：

目的探讨双相真菌申克孢子丝菌（复合体）子宫颈感染的临床特点，为进一步提高实验室及临床诊断水平提供资料。方法分析1例申克孢子丝菌（复合体）子宫颈感染临床表现与实验室诊断过程，检索近年来国内外主要文献进行复习。结果患者阴道分泌物镜检见成团的革兰染色阳性、圆形、卵圆形孢子，较球菌大，较酵母样真菌孢子小。37℃血平皿培养，形成边缘不齐、表面有褶皱、干燥、有韧性不易挑取的白色菌落；革兰氏染色镜下见染色阳性酵母样芽生孢子。25℃SDA培养，形成中心有白色褶皱，周围绒毛样的丝状真菌菌落形态，直接涂片镜检见大量有隔菌丝、孢子。上述特征符合申克孢子丝菌。国内外文献检索，申克孢子丝菌感染多为皮肤局限性、肺炎、骨关节等病例，偶有累及局部淋巴结的病例，仅少数艾滋病等免疫力极度低下患者为全身播散性感染。结论申克孢子丝菌所致子宫颈感染罕见，掌握其在人体内与不同条件下培养菌落的特征有助于及时诊断。

关键词: 双相真菌, 申克孢子丝菌, 子宫颈, 感染

Abstract:

Objective To investigate the clinical characteristics of sporotrichosis in the uterine cervix caused by Sporothrix schenckii). Methods A case of Sporothrix schenckii in the uterine cervixhad been analyzed. Review of major related literatures at domestic and foreign in recent years was also performed. Results Microscope examination of vaginal secretions showed lumpy, Gram-positive, round-shaped and oval-spores, which were larger than normal Gram-positive coccus and smaller than yeast-like fungal spores. Blood plate culture at 37℃ showed white colony with marginal edges, dry and wrinkled surface. It was not easy to pick up sample from the tough surface. The Gram stain of this white colony showed Gram-positive yeast-like spores. The, filamentous fungus-like colonies with white folds in centerhas been formed at 25℃ in the SDA culture. These characteristics were consistent with clinical laboratory diagnostic features of Sporothrix schenckii infection. Conclusion The cervix infection caused by Sporothrix schenckii was rare, and the characteristics of culturing colonies under different conditions would be helpful to timely diagnosis in the laboratory.

Key words: dimorphism fungi, sporotrichosis, uterine cervix, infection

中图分类号:

R519.8

张一男, 刘晓娜, 杨晶, 刘玥姣, 石铭, 薛文成. 子宫颈感染孢子丝菌1例[J]. 中国真菌学杂志, 2019, 14(1): 47-49.

ZHANG Yin-an, LIU Xiao-na, YANG Jing, LIU Yue-jiao, SHI Ming, XUE Wen-cheng. A case of sporotrichosis in the uterine cervix[J]. Chinese Journal of Mycology, 2019, 14(1): 47-49.

参考文献

[1] Bonifaz A, Tirado-Sánchez A.Cutaneous disseminated and extracutaneous sporotrichosis:current status of a complex disease[J]. J Fungi (Basel),2017,3(1):1-13.
[2] Chakrabarti A, Bonifaz A, Gutierrez-Gualhardo MC, et al. Global epidemiology of sporotrichosis[J].Med Mycol, 2015,53(1):3-14.
[3] 吕莎,李福秋.孢子丝菌病的临床表现诊疗与变迁[J]. 皮肤科学通报,2017,35(5):556-564.
[4] Arenas R, Sánchez-Cardenas CD, Ramirez-Hobak L, et al.Sporotrichosis:from KOH to molecular biology[J]. J Fungi (Basel), 2018,4(2):1-10.
[5] 中华医学会皮肤性病学分会真菌学组.孢子丝菌病诊疗指南[J]. 中华皮肤科杂志,2016,49(7):456-459.
[6] Fernández MS, Lucchelli JM, Lombardi D, et al. Cavitary pulmonary sporotrichosis:case report and literature review[J]. Mycopathologia,2017,182(11-12):1119-1123.
[7] Farooqui SM, Youness H.The infection returns:a case of pulmonary sporotrichosis relapse after chemotherapy[J]. Case Rep Med,2018:1384029. DOI:10.1155/2018/1384029.
[8] 蒋佳佳,刘栋华.皮肤播散型孢子丝菌病[J].临床皮肤科杂志,2017,47(12):858-860.
[9] 刘雯,邵丽芳,赵庆利,等. 皮肤播散型孢子丝菌病1例并文献复习[J]. 中国真菌学杂志,2018,13(1):30-33.
[10] Orofino C, Marques de Macedo P, Messias R, et al. Sporotrichosis:an update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics[J]. An Brasil Dermatol,2017,92(5):606-620.
[11] Ferreira CP,Nery JA,de Almeida AC, et al.Parinaud's oculoglandular syndrome associated with Sporothrix schenckii[J]. ID Cases,2014,1(3):38-39.
[12] Antonio LF, Pimentel MI, Lyra MR, et al.Sporothrix schenckii Sensu Lato identification in fragments of skin lesion cultured in NNN medium for differential diagnosis of cutaneous leishmaniasis[J].Diagn Microbiol Infect Dis, 2017,87(2):118-120.
[13] 姜媛,孔庆涛,张征,等.皮肤淋巴管型孢子丝菌病1例[J].中国真菌学杂志,2016,11(6):376-377.
[14] Yagnik KJ, Skelton WP 4th, Olson A, et al. A rare case of disseminated Sporothrix schenckii with bone marrow involvement in a patient with idiopathic CD4 lymphocytopenia[J].ID Cases,2017,(9):70-72.

[1]	丁翔宇, 贾晨虹, 张古英, 李倩, 刘艳辉. 普外科婴幼儿侵袭性真菌感染的高危因素分析与评分系统建立[J]. 中国真菌学杂志, 2020, 15(6): 331-337,353.
[2]	杨靖娴, 邵冬华, 郭莉娜, 刘静, 徐英春, 梁国威. 北京某医院侵袭性念珠菌感染的菌株分布及药敏分析[J]. 中国真菌学杂志, 2020, 15(6): 359-363,370.
[3]	郭艳阳, 孙笑然, 海璐明, 闫东, 朱冠男, 马翠玲, 王刚, 付萌. 人工性脂膜炎伴发近平滑念珠菌感染1例分析[J]. 中国真菌学杂志, 2020, 15(6): 368-370.
[4]	朱红梅, 温海. 特比萘芬在皮下及深部真菌感染中的临床应用[J]. 中国真菌学杂志, 2020, 15(6): 374-377.
[5]	刘瞳瞳, 杜琨. 施慧早产儿侵袭性真菌感染的危险因素[J]. 中国真菌学杂志, 2020, 15(6): 381-384.
[6]	程颖, 陈丹. 儿童浅部真菌感染的临床分析[J]. 中国真菌学杂志, 2020, 15(5): 288-292.
[7]	朱红梅, 温海. 特比萘芬在浅表真菌感染中的临床应用[J]. 中国真菌学杂志, 2020, 15(5): 297-303.
[8]	李敬波, 徐宇, 张芙蓉. Majocchi肉芽肿研究进展[J]. 中国真菌学杂志, 2020, 15(5): 306-309.
[9]	黄丽, 龚豪, 张春莲, 方彩云. 非妊娠妇女阴道真菌感染情况调查[J]. 中国真菌学杂志, 2020, 15(4): 213-217.
[10]	邵霞, 舒国斌, 乔建军. 犬小孢子菌引起皮肤感染6例误诊分析[J]. 中国真菌学杂志, 2020, 15(4): 227-229.
[11]	陶鹏飞, 杨欣平, 李正伦, 周奇文, 闵海燕, 钱庆锦. 30例艾滋病合并侵袭性隐球菌病的临床特征及治疗转归[J]. 中国真菌学杂志, 2020, 15(3): 150-153.
[12]	李晓君, 谭俊青, 潘慧娟, 王康椿. 老年患者导尿管相关念珠菌泌尿系感染菌株分布及药敏分析[J]. 中国真菌学杂志, 2020, 15(3): 161-163.
[13]	刘庆华, 王成, 胡芸倩, 董雪, 李强. 普通裂褶菌致肺部感染1例[J]. 中国真菌学杂志, 2020, 15(3): 173-174.
[14]	马玉帛, 张逸, 黄晨, 王晓雯, 李若瑜. 自然杀伤细胞在真菌感染免疫的研究进展[J]. 中国真菌学杂志, 2020, 15(3): 175-178.
[15]	郑晓丽, 陈官芝, 刘维达. 抗真菌药物的免疫调节作用[J]. 中国真菌学杂志, 2020, 15(3): 179-182.