白念珠菌White-Gray-Opaque表型转换系统的研究进展

中国真菌学杂志　 2018, Vol. 13 　Issue (6): 367-370.

白念珠菌White-Gray-Opaque表型转换系统的研究进展

王钰婷^1,2, 刘锦燕², 赵悦^1,2, 孟玲宁^1,2, 项明洁^1,2

1. 上海交通大学医学院附属瑞金医院检验科, 上海 200025;
2. 上海交通大学医学院附属瑞金医院卢湾分院放免检验科, 上海 200020

收稿日期:2018-03-10 出版日期:2018-12-28 发布日期:2018-12-28
通讯作者: 项明洁,E-mail:mjxiang123456@126.com E-mail:mjxiang123456@126.com
作者简介:王钰婷,女(汉族),硕士研究生在读.E-mail:yutingwang95@163.com
基金资助:
上海市卫计委课题（201740069）；上海市黄浦区卫计委课题（HKM201702）

Research progress of White-Gray-Opaque phenotypic switching system in Candida albicans

WANG Yu-ting^1,2, LIU Jin-yan², ZHAO Yue^1,2, MENG Ling-ning^1,2, XIANG Ming-jie^1,2

1. Department of Clinical Laboratory, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China;
2. Radioimmunology and Clinical Laboratory, Luwan Branch, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200020, China

Received:2018-03-10 Online:2018-12-28 Published:2018-12-28

摘要/Abstract

摘要：

白念珠菌是人类常见的条件致病菌，而表型转换是其重要的生物学特性，各个表型在宿主适应、感染、毒力及不同生活阶段发挥着不同作用。White-Gray-Opaque表型转换是白念珠菌的一种新型转换系统，该文从White-Gray-Opaque表型特点、影响表型转换的调控因素、表型与宿主的相互作用等方面综述近年来白念珠菌在该表型系统中的研究进展，希望通过理解其形态调节的机制以寻找感染治疗的新策略。

关键词: 白念珠菌, 表型转换, 调节因子, 毒力

Abstract:

Candida albicans is a common opportunistic fungal pathogen of humans. An important biological feature of this fungus is its phenotypic transition, and diverse morphological phenotypes play distinct roles in host adaptation,infection and virulence during different life stages. White-Gray-Opaque phenotypic switching system is a novel phenotypic transition in Candida albicans. In this review, research achievements about this phenotypic transition were mentioned,including the traits of White-Gray-Opaque phenotype, the key regulatory factors and the interaction with hosts. In a nutshell, understanding about the molecular mechanisms of this phenotypic transition in Candida albicans might be beneficial to the discovery of novel infection treatment strategies.

Key words: Candida albicans, phenotypic transitions, regulatory factors, virulence

中图分类号:

R379.4

王钰婷, 刘锦燕, 赵悦, 孟玲宁, 项明洁. 白念珠菌White-Gray-Opaque表型转换系统的研究进展[J]. 中国真菌学杂志, 2018, 13(6): 367-370.

WANG Yu-ting, LIU Jin-yan, ZHAO Yue, MENG Ling-ning, XIANG Ming-jie. Research progress of White-Gray-Opaque phenotypic switching system in Candida albicans[J]. Chinese Journal of Mycology, 2018, 13(6): 367-370.

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