MALDI-TOF MS在病原性丝状真菌鉴定中的应用进展

摘要/Abstract

摘要：

丝状真菌临床感染率逐年攀升，且丝状真菌种类繁多，耐药谱多样，对病原性丝状真菌进行准确种属鉴定具有重要临床意义。基质辅助激光解吸电离飞行时间质谱（MALDI-TOF MS）是新近兴起的微生物菌种快速鉴定技术，已应用于临床细菌及酵母菌菌种鉴定且成效显著，但在丝状真菌鉴定方面，其鉴定效能及应用程度略逊。该文综述了近年来在这一方面的研究进展。

关键词: MALDI-TOF MS, 丝状真菌, 鉴定

Abstract:

Invasive infections caused by filamentous fungi have been increasing in recent years.Accurate identification of filamentous fungi isolates has important role in clinical treatment of filamentous fungi infections owing to the great variety of antifungal susceptibility profiles among different species of those microorganisms.Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) has been revealed to be an emerging technology in the field of microbe identification and performed outstandingly in bacteria and yeasts identification.The performance of this novel technology in filamentous fungi identification,however,remained inferior and less-employed than that in bacteria and yeasts identification.This paper reviews some representative research aiming on working this dilemma out in the global and the remarkable developments obtained during this process.

Key words: MALDI-TOF MS, filamentous fungi, identification

中图分类号:

R379

李颖, 徐英春. MALDI-TOF MS在病原性丝状真菌鉴定中的应用进展[J]. 中国真菌学杂志, 2017, 12(6): 378-381.

LI Ying, XU Ying-chun. Developments of MALDI-TOF MS in identification of clinical filamentous fungi[J]. Chinese Journal of Mycology, 2017, 12(6): 378-381.

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