NLRP3炎症小体与真菌感染

中国真菌学杂志　 2017, Vol. 12 　Issue (3): 162-167.

NLRP3炎症小体与真菌感染

徐志庆^1,2, 吴大强^1,2, 邵菁^1,2, 汪天明^1,2, 汪长中^1,2

1. 安徽中医药大学中西医结合临床学院, 合肥 230038;
2. 安徽省中医药科学院中西医结合研究所, 合肥 230038

收稿日期:2017-02-02 出版日期:2017-06-28 发布日期:2017-06-28
通讯作者: 汪长中,E-mail:ahwcz63@sina.com E-mail:ahwcz63@sina.com
作者简介:徐志庆,女(汉族),硕士,助教.E-mail:634763910@qq.com
基金资助:
国家自然科学基金（81573725）

The effects of NLRP3 inflammasome in fungal infection

XU Zhi-qing^1,2, WU Da-qiang^1,2, SHAO Jing^1,2, WANG Tian-ming^1,2, WANG Chang-zhong^1,2

1. School of Integrated Traditional and Western Medicine, Anhui University of Chinese Medicine, Hefei 230038, China;
2. Institute of Integrated Traditional and Western Medicine, Anhui Academy of Chinese Medicine, Hefei 230038, China

Received:2017-02-02 Online:2017-06-28 Published:2017-06-28

摘要/Abstract

摘要：

在真菌感染时，宿主免疫细胞通过模式识别受体（PRR）识别β-葡聚糖等多种病原体相关分子模式（PAMP）引发抗真菌天然免疫。NLR家族中的NLRP3与ASC和caspase-1共同组成NLRP3炎症小体，参与或调控真菌感染。该文就近年来关于NLRP3炎症小体在真菌感染中的作用作一综述。

关键词: 白念珠菌, NLRP3炎症小体, 天然免疫, 模式识别受体, 病原体相关分子模式

Abstract:

In fungal infection,host immune cells recognized pathogen associated molecular patterns (PAMPs),such as beta-glucan,by pattern recognition receptors (PRRs) and trigger innate immunity against fungi.NLRP3,a member of NLR family,together with ASC and caspase-1,constituting NLRP3 inflammasome,participated in or controls fungal infection.In this paper,we reviewed the role of NLRP3 inflammasome in the fungal infection in recent years.

Key words: Candida albicans, NLRP3 inflammasome, innate immunity, pattern recognition receptors (PRRs), pathogen associated molecular patterns (PAMPs)

中图分类号:

R519

徐志庆, 吴大强, 邵菁, 汪天明, 汪长中. NLRP3炎症小体与真菌感染[J]. 中国真菌学杂志, 2017, 12(3): 162-167.

XU Zhi-qing, WU Da-qiang, SHAO Jing, WANG Tian-ming, WANG Chang-zhong. The effects of NLRP3 inflammasome in fungal infection[J]. Chinese Journal of Mycology, 2017, 12(3): 162-167.

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