影响白念珠菌表型的信号通路及其转录因子研究进展

摘要/Abstract

摘要：

白念珠菌是最常见的人类条件致病性真菌。白念珠菌在接受环境刺激信息后，能通过多种信号转导途径使菌体发生形态、毒力等各种表型转换，从而适应生长环境，易于在宿主体内潜伏或致病。该文对白念珠菌表型转换信号通路中主要转录因子的最新研究进展进行了概述，重点介绍介导白念珠菌形态转换和毒力等表型的信号转导主要通路:cAMP-PKA通路和MAPK通路，这些通路的终点都是相关转录因子，如Efg1、Cph1。转录因子能与基因启动子结合，调控白念珠菌相应基因的转录，从而促进或抑制信号的传达，影响白念珠菌的增殖、形态转变、致病力等。可为相关研究工作者进一步了解白念珠菌表型转换的调节机制提供参考。

关键词: 白念珠菌, 表型, 表型转换, 信号通路, 转录因子

Abstract:

Candida albicans, responsing signals to adapt to environment by a variety of signal transduction pathways, is the most common human opportunistic fungi.The most important signal transduction pathways that mediate the morphogenesis and virulence in Candida albicans are cAMP-PKA pathway and MAPK pathway.Transcription factors are the endpoints of these pathways, such as Efg1 and Cph1.Transcription factors can regulate the transcription of genes by binding with their promoters in Candida albicans.Regulating transcription factors can promote or inhibit the signal transduction, and thus affecting the proliferation, morphogenesis, virulence, etc, of Candida albicans.In this review, we demonstrated the major transcription factors of phenotypic transition signal pathways in Candida albicans to further understand the phenotype and regulation mechanism of Candida albicans.

Key words: C.albicans, phenotype, phenotypic transition, signal pathways, TF

中图分类号:

R379.4

王丽红, 张金宇, 阎澜, 姜远英, 曹永兵, 洪浩. 影响白念珠菌表型的信号通路及其转录因子研究进展[J]. 中国真菌学杂志, 2017, 12(2): 114-119.

WANG Li-hong, ZHANG Jin-yu, YAN Lan, JIANG Yuan-ying, CAO Yong-bing, HONG Hao. The transcription factors of phenotypic transition signal pathways in Candida albicans[J]. Chinese Journal of Mycology, 2017, 12(2): 114-119.

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