某院念珠菌尿的临床感染特征及其耐药趋势分析

中国真菌学杂志　 2017, Vol. 12 　Issue (2): 102-105.

某院念珠菌尿的临床感染特征及其耐药趋势分析

曹艳云¹, 房华², 蔡海斌¹, 徐顺明¹

1. 上海市浦东新区人民医院皮肤科, 上海 201299;
2. 上海市浦东新区人民医院检验科, 上海 201299

收稿日期:2017-01-22 出版日期:2017-04-28 发布日期:2017-04-28
通讯作者: 徐顺明,E-mail:13641930667@163.com E-mail:13641930667@163.com
作者简介:曹艳云,女(汉族),硕士,主治医师.E-mail:cyy1980142003@sohu.com

Clinical infection characteristics and analysis of drug resistance trend of candiduria in hospital

CAO Yan-yun¹, FANG Hua², CAI Hai-bin¹, XU Shun-ming¹

1. Department of Dermatology, Pudong New Area People's Hospital, Shanghai 201299;
2. Department of Laboratory Medicine, Pudong New Area People's Hospital, Shanghai 201299

Received:2017-01-22 Online:2017-04-28 Published:2017-04-28

摘要/Abstract

摘要：

目的调查和分析本院念珠菌尿的临床感染特征及耐药趋势，为临床合理选用抗真菌药物提供依据。方法以2013~2016年住院患者尿沉渣中念珠菌培养阳性者为研究对象，检出的菌株采用科玛嘉显色培养基进行鉴定，并通过ATB Fungu 3酵母样真菌药敏试剂盒进行药物敏感性试验。结果共分离出念珠菌株202例，其中白念珠菌最多（79.1%），其次为热带念珠菌（10.7%），近平滑念珠菌（5.1%）及克柔念珠菌（5.1%）。临床检出量以急诊内科最多（83例），其次为泌尿外科和内分泌科（均为21例）。药敏结果示:念珠菌对两性霉素B和5-氟胞嘧啶较敏感，念珠菌对氟康唑的耐药率逐年增加，对伏立康唑和伊曲康唑耐药率处于波动状态，但2016年的耐药率明显升高。结论念珠菌尿分离菌仍以白念珠菌为主。念珠菌对两性霉素B和5-氟胞嘧啶耐药性低，对唑类均有不同程度的耐药，且耐药率有升高的趋势。

关键词: 念珠菌, 念珠菌尿, 耐药性

Abstract:

Objective To investigate and analyze the clinical infection characteristics and drug resistance trend of candiduria, to provide evidence for selection of antifungal drugs.Methods Patients who cultured Candida positive in urinary sediment were collected from 2013 to 2016.The strains were identified by CHRO Magar chromogenic medium and the drug susceptibility test was performed with ATB Fungu 3 reagent.Results A total of 202 strains of Candida were isolated, including C.albicans (79.1%), C.tropicalis (10.7%), C.parapsilosis and C.krusei (respectively 5.1%).The Candida were mainly found in emergency department (83 cases), followed by urology (21 cases) and endocrinology (21 cases).Drug sensitivity results showed that Amphotericin B and 5-fluorocytosine had a strong antibacterial activity against Candida.The resistance rate of Candida to fluconazole increased year by year.Candida's resistant to voriconazole and itraconazole was in a fluctuating state, and the resistance rate of Candida was significantly higher in 2016.Conclusion C.albicans was still the most predominant pathogen of candiduria.The drug resistance rates of amphotericin B and 5-fluorocytosine were the lowest, while there was a genus difference in drug resistance of the azoles, and the trends of drug resistance were becoming more serious.

Key words: Candida, candiduria, drug resistance

中图分类号:

R519.3

曹艳云, 房华, 蔡海斌, 徐顺明. 某院念珠菌尿的临床感染特征及其耐药趋势分析[J]. 中国真菌学杂志, 2017, 12(2): 102-105.

CAO Yan-yun, FANG Hua, CAI Hai-bin, XU Shun-ming. Clinical infection characteristics and analysis of drug resistance trend of candiduria in hospital[J]. Chinese Journal of Mycology, 2017, 12(2): 102-105.

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