1%卢立康唑乳膏治疗体股癣的疗效和安全性研究

中国真菌学杂志　 2017, Vol. 12 　Issue (1): 42-44.

1%卢立康唑乳膏治疗体股癣的疗效和安全性研究

朱敏, 粟慧琳, 李莉, 程本霖, 朱均昊, 章强强

复旦大学附属华山医院皮肤科, 上海 200040

收稿日期:2017-02-10 出版日期:2017-02-28 发布日期:2017-02-28
作者简介:朱敏,女（汉族）,博士,副主任医师.E-mail：zhumin3000@hotmail.com
基金资助:
中国中西医结合学会皮肤性病专业委员会临床研究基金（CAIM-LLKZ-007）

Evaluation of efficacy and safety of 1% luliconazole cream in the treatment of tinea corporis and tinea cruris

ZHU Min, SU Hui-lin, LI Li, CHENG Ben-lin, ZHU Jun-hao, ZHANG Qiang-qiang

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040

Received:2017-02-10 Online:2017-02-28 Published:2017-02-28

摘要/Abstract

摘要：

目的评价1%卢立康唑乳膏治疗体股癣的疗效和安全性。方法采用单中心、随机、单盲、平行对照（1%盐酸特比萘芬乳膏）试验。每天外用药物1次，疗程2周。在入组时、治疗1周和2周、停药2周时进行观察和评价。结果试验组30例、对照组28例患者完成随访并录入统计。有效率：试验组和对照组在治疗1周时分别为43.33%和28.57%；治疗2周时，分别为96.67%和85.71%；停药2周时分别为96.67%和100.00%。两组间均无统计学差异。真菌清除率：试验组和对照组在治疗1周时均为50.00%；治疗2周时分别为96.67%和85.71%；停药2周时分别为96.67%和100.00%。两组间均无统计学差异。本研究未见不良反应。结论 1%卢立康唑乳膏治疗体股癣有效、安全。

关键词: 卢立康唑, 特比萘芬, 体癣, 股癣

Abstract:

Objective To evaluate the efficacy and safety of 1% luliconazole cream in the treatment of tinea corporis and tinea cruris.Methods A single-center,single-blind,randomized,positive drug (1% terbinafine hydrochloride cream) controlled trial was conducted.Both 1% luliconazole cream and 1% terbinafine hydrochloride cream were applied once daily for 2 weeks to the rashes.Patients were evaluated at 0 (baseline),1,2 and 4 weeks.Results Thirty cases in the trial group and 28 cases in the control group were evaluated.The effective rate at 1 week was 43.33% in the trial group and 28.57% in the control group (P>0.05);96.67% versus 85.71% at 2 weeks and 96.67% versus 100.00% at 4 weeks respectively (P>0.05).Mycological cure rates at 1 week both were 50% in the trial group and control group;96.67% versus 85.71% at 2 weeks and 96.67% versus 100.00% at 4 weeks respectively (P>0.05).Treatment-related adverse events were not seen in this study.Conclusion This study suggests that 1% luliconazole cream was effective and safe in the treatment of tinea corporis and tinea cruris.

Key words: luliconazole, terbinafine, tinea corporis, tinea cruris

中图分类号:

R756.2

朱敏, 粟慧琳, 李莉, 程本霖, 朱均昊, 章强强. 1%卢立康唑乳膏治疗体股癣的疗效和安全性研究[J]. 中国真菌学杂志, 2017, 12(1): 42-44.

ZHU Min, SU Hui-lin, LI Li, CHENG Ben-lin, ZHU Jun-hao, ZHANG Qiang-qiang. Evaluation of efficacy and safety of 1% luliconazole cream in the treatment of tinea corporis and tinea cruris[J]. Chinese Journal of Mycology, 2017, 12(1): 42-44.

[1]	朱红梅, 温海. 特比萘芬在皮下及深部真菌感染中的临床应用[J]. 中国真菌学杂志, 2020, 15(6): 374-377.
[2]	特比萘芬临床应用专家共识工作组. 特比萘芬临床应用专家共识[J]. 中国真菌学杂志, 2020, 15(5): 257-261.
[3]	余敏, 纪明开. 乳房难辨认癣1例[J]. 中国真菌学杂志, 2020, 15(5): 296-296,305,309.
[4]	朱红梅, 温海. 特比萘芬在浅表真菌感染中的临床应用[J]. 中国真菌学杂志, 2020, 15(5): 297-303.
[5]	朱红梅, 温海. 特比萘芬耐药皮肤癣菌的研究进展[J]. 中国真菌学杂志, 2020, 15(4): 253-256.
[6]	张焕梅. 卢立康唑乳膏联合柳烯酸溶液喷雾剂治疗马拉色菌毛囊炎疗效观察[J]. 中国真菌学杂志, 2020, 15(1): 52-54.
[7]	李浩慧, 郑跃, 尹颂超, 温静, 赖维. 疑似反转型银屑病表现的红色毛癣菌感染1例[J]. 中国真菌学杂志, 2019, 14(6): 374-375.
[8]	中国体癣和股癣诊疗指南工作组. 中国体癣和股癣诊疗指南(2018修订版)[J]. 中国真菌学杂志, 2019, 14(1): 1-3.
[9]	邵霞, 乔建军. 长期误诊的颈部难辨认癣1例[J]. 中国真菌学杂志, 2019, 14(1): 45-46.
[10]	胡小平, 高露娟, 尤立平, 李若瑜. 肾移植术后合并红色毛癣菌肉芽肿1例报道[J]. 中国真菌学杂志, 2018, 13(4): 241-243.
[11]	吴燕, 孔健, 袁海龙, 张福成. 复方盐酸特比萘芬凝胶抗皮肤癣菌感染的组织病理学疗效观察[J]. 中国真菌学杂志, 2017, 12(5): 283-287.
[12]	曹艳云, 徐顺明. 犬小孢子菌病20例临床分析及文献回顾[J]. 中国真菌学杂志, 2017, 12(1): 29-33,44.
[13]	雷文知, 都琳, 卫凤莲, 廖万清, 温海. 1%卢立康唑乳膏与1%特比萘芬乳膏治疗股癣的随机、对照、双盲研究[J]. 中国真菌学杂志, 2017, 12(1): 38-41.
[14]	杨静, 董碧麟, 江萍, 尹婧, 陈尊义, 张伟明, 夏凡, 赖彬, 童中胜. 1%卢立康唑乳膏治疗足癣的临床疗效观察[J]. 中国真菌学杂志, 2017, 12(1): 45-48.
[15]	高方铭, 易江华, 叶兴东, 肖常青, 高爱莉, 刘玉梅, 戴向农. 1%卢立康唑乳膏治疗念珠菌性包皮龟头炎多中心疗效观察[J]. 中国真菌学杂志, 2016, 11(6): 381-384.