卢立康唑乳膏与酮康唑乳膏外用治疗花斑糠疹疗效观察

中国真菌学杂志　 2016, Vol. 11 　Issue (5): 307-309,315.

卢立康唑乳膏与酮康唑乳膏外用治疗花斑糠疹疗效观察

陈锐君, 张金燕, 陈柏叡, 曹卉, 林达闽, 徐明, 卢万丁, 郑礼宝

福州市皮肤病防治院, 福州 350001

收稿日期:2016-07-12 出版日期:2016-10-28 发布日期:2016-10-28
通讯作者: 陈柏叡,E-mail:1390812047@qq.com E-mail:1390812047@qq.com
作者简介:陈锐君,女(汉族),本科,初级检验技师.E-mail:mone882003@qq.com
基金资助:
中国中西医结合学会皮肤性病专业委员会临床研究基金

Efficacy of luliconazole cream in patient with pityriasis versicolor

CHEN Rui-jun, ZHANG Jin-yan, CHEN Bo-rui, CAO Hui, LIN Da-min, XU Ming, LU Wan-ding, ZHENG Li-bao

Fuzhou Dermatosis Prevention Hospital, Fuzhou 350001

Received:2016-07-12 Online:2016-10-28 Published:2016-10-28

摘要/Abstract

摘要：

目的观察卢立康唑乳膏1次/d疗法治疗花斑糠疹的效果及安全性。方法将参与实验的花斑糠疹患者80例随机分组，实验组每晚1次外用卢立康唑乳膏，对照组早晚各1次外用酮康唑乳膏，连续2周，于治疗前、停药后2周、停药后6周分别进行症状和体征评分。结果实验组及对照组治疗结束停药后2周有效率分别为54.5%和56.3%，真菌转阴率为81.8%和87.5%；治疗结束停药后6周则有效率则分别为63.6%和62.5%，真菌转阴率为93.9%和93.8%，均无显著差异（P>0.05）。按皮损颜色分组分析，白色花斑糠疹无论在实验组或对照组，其有效率均明显低于褐色的及红色的皮损，且均未发现明确的药物不良反应。结论卢立康唑乳膏1次/d，2周外用疗法治疗花斑糠疹疗效好，简便易行，安全性高。

关键词: 花斑糠疹, 卢立康唑, 疗效

Abstract:

Objective To observe the efficacy and safety of once-daily luliconazole cream in treatment of pityriasis versicolor.Methods There were 80 patients with pityriasis versicolor randomly enrolled into trial group treated with luliconazole cream (once daily) for 2 weeks and into control group treated with 2% ketaconazole cream (twice daily) for 2 weeks.The clinical observations were taken on baseline,2 week and 6 week after the treatment.Results The clinical effective rates of 2 groups 2 week after the treatment were 54.5% and 56.3%;the mycological clearance rates of 2 groups were 81.8% and 87.5%;both results had no statistically significant difference (P>0.05).The clinical effects of 2 groups 6 week after the treatment were 63.6% and 62.5%;the mycological effects of 2 groups were 93.9% and 93.8%;both results had no statistically significant difference (P>0.05).The theraputic result of the white-type eruption obviously lower than that of the brown-type and red-type eruption.Besides,no side effects were been found in both groups.Conclusions The method of luliconazole cream once-daily for 2 weeks is effective and safe in the treatment of pityriasis versicolor.

Key words: pityriasis versicolor, luliconazole, efficacy

中图分类号:

R756.9

陈锐君, 张金燕, 陈柏叡, 曹卉, 林达闽, 徐明, 卢万丁, 郑礼宝. 卢立康唑乳膏与酮康唑乳膏外用治疗花斑糠疹疗效观察[J]. 中国真菌学杂志, 2016, 11(5): 307-309,315.

CHEN Rui-jun, ZHANG Jin-yan, CHEN Bo-rui, CAO Hui, LIN Da-min, XU Ming, LU Wan-ding, ZHENG Li-bao. Efficacy of luliconazole cream in patient with pityriasis versicolor[J]. Chinese Journal of Mycology, 2016, 11(5): 307-309,315.

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