(1,3)-β-D-葡聚糖检测对侵袭性真菌感染临床价值的再评价

中国真菌学杂志　 2016, Vol. 11 　Issue (5): 269-271,274.

(1,3)-β-D-葡聚糖检测对侵袭性真菌感染临床价值的再评价

夏吉荣, 牛司强, 曹炬

重庆医科大学附属第一医院检验科, 重庆 400016

收稿日期:2015-11-28 出版日期:2016-10-28 发布日期:2016-10-28
作者简介:夏吉荣,男(汉族),本科,副主任技师.E-mail:xjr196352@163.com

Re-evaluation of the clinical value of (1,3)-β-D-glucan detection in the invasive fungal infections

XIA Ji-rong, NIU Si-qiang, Cao Ju

The first affiliated hospital of Chongqing medical university, Chongqing 400016

Received:2015-11-28 Online:2016-10-28 Published:2016-10-28

摘要/Abstract

摘要：

目的探讨（1，3）-β-D-葡聚糖检测（G试验）在侵袭性真菌病诊断中的价值。方法回顾性研究重庆医科大学附属第一医院2014年1~6月间临床G试验的住院患者结果，分析G试验诊断真菌感染的敏感性、特异性、符合率、阳性预测值、阴性预测值、约登指数等能力指标。结果真菌感染组G试验检测值228.4±250.1 pg/mL，非真菌感染组G试验检测值32.6±13.6 pg/mL，两组间有显著统计学差异（P<0.001）；G试验对真菌感染的敏感性、特异性、符合率、阳性预测值、阴性预测值、约登指数分别为83%、92%、88%、89%、87%、0.75。结论 G试验是真菌感染的重要早期实验室指标之一，对其合理应用可有效提高真菌感染的诊治水平，特别是阴性结果对排除真菌感染的意义更大。

关键词: (1,3)-β-D-葡聚糖, G试验, 侵袭性真菌病

Abstract:

Objective To investigate the diagnostic value of (1,3)-β-D-glucan test (G test) in invasive fungal disease.Methods Retrospectively study the inpatient results of clinical G test from Jan.2014 to Jun.2014 at The First Affiliated Hospital of Chongqing Medical University and analyse the sensitivity,specificity,coincidence rate,positive predictive value,negative predictive value and Youden index of G test in fungal infection.Results The G test value of fungal infection group was 228.4±250.1 pg/mL,and the G test value of non-fungal infection group was 32.6±13.6 pg/mL.There were significant differences between the two groups (P<0.001).The sensitivity,specificity,coincidence rate,positive predictive value,negative predictive value and Youden index of G test in fungal infection were 83%,92%,88%,89%,87%,0.75,respectively.Conclusion G test is one of important early laboratory indexes in fungal infection,and the rational use of G test can effectively improve the diagnostic ability of fungal infection,especially for the negative exlusion.

Key words: (1,3)-β-D-glucan, G test, invasive fungal disease (IFD)

中图分类号:

R519

夏吉荣, 牛司强, 曹炬. (1,3)-β-D-葡聚糖检测对侵袭性真菌感染临床价值的再评价[J]. 中国真菌学杂志, 2016, 11(5): 269-271,274.

XIA Ji-rong, NIU Si-qiang, Cao Ju. Re-evaluation of the clinical value of (1,3)-β-D-glucan detection in the invasive fungal infections[J]. Chinese Journal of Mycology, 2016, 11(5): 269-271,274.

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