国内多中心甲真菌病病原菌流行病学调查

中国真菌学杂志　 2015, Vol. 10 　Issue (4): 197-202.

国内多中心甲真菌病病原菌流行病学调查

王爱平¹, 余进¹, 万喆¹, 李福秋², 曾敬思³, 刘维达⁴, 章强强⁵, 郝飞⁶, 冉玉平⁷, 席丽艳⁸, 赖维⁹, 李若瑜¹

1. 北京大学第一医院皮肤性病科, 北京 100034;
2. 吉林大学第二医院皮肤科, 长春 130041;
3. 华中科技大学同济医学院附属协和医院皮肤科, 武汉 430022;
4. 中国医学科学院北京协和医学院皮肤病研究所真菌科, 南京 210042;
5. 复旦大学附属华山医院皮肤科, 上海 200040;
6. 第三军医大学第一附属医院皮肤科, 重庆 400038;
7. 四川大学华西医院皮肤科, 成都 610041;
8. 中山大学孙逸仙纪念医院皮肤科, 广州 510120;
9. 中山大学附属第三医院皮肤科, 广州 510630

收稿日期:2014-12-02 出版日期:2015-08-28 发布日期:2015-08-28
通讯作者: 李若瑜,E-mail:lry0660@gmail.com E-mail:lry0660@gmail.com
作者简介:王爱平,女(汉族),学士,主任医师.E-mail:wangap@medmail.com.cn

Multi-center epidemiological survey of pathogenic fungi of onychomycosis in China

WANG Ai-ping¹, YU Jin¹, WAN Zhe¹, LI Fu-qiu², ZENG Jing-si³, LIU Wei-da⁴, ZHANG Qiang-qing⁵, HAO Fei⁶, RAN Yu-ping⁷, XI Li-yan⁸, LAI Wei⁹, LI Ruo-yu¹

1. Department of Dermatology & Venereology, First Hospital, Peking University, Beijing 100034;
2. Department of Dermatology, the Second Hospital of Jilin University, Changchun 130041;
3. Department of Dermatology & Venereology, Union Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan 430022;
4. Department of mycology, Insitute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042;
5. Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040;
6. Department of Dermatology and Venereology, Southwest Hospital, Third Military Medical University, Chongqing 400038;
7. Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu 610041;
8. Department of Dermatology, the Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120;
9. Department of Dermatology, the third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630

Received:2014-12-02 Online:2015-08-28 Published:2015-08-28

摘要/Abstract

摘要：

目的了解国内甲真菌病病原菌的种类和构成情况,掌握流行病学资料。方法对真菌镜检阳性的1 428例甲真菌病患者进行真菌培养和临床分析。结果真菌培养阳性率为53.9%,分离出病原菌800株。其中皮肤癣菌占84.0%,以红色毛癣菌为主(80.9%),其次为指(趾)间毛癣菌和絮状表皮癣菌。酵母菌占11.4%,以念珠菌属为主(10.1%),尤以近平滑念珠菌为主,其次为白念珠菌和热带念珠菌。其他霉菌占4.6%,以枝顶孢霉为主(2.3%),其次曲霉属、青霉属、毛壳菌属、镰刀菌属和帚霉属等。结论本研究显示甲真菌病病原菌以皮肤癣菌为主,其次为酵母菌和霉菌。

关键词: 甲真菌病, 病原菌, 多中心, 流行病学研究

Abstract:

Objective The aim of this study was to investigate the epidemiology of pathogenic fungi of onychomycosis in China.Methods Fungal culture and clinical analysis were performed on 1 428 cases of onychomycosis using positive direct microscopic examination.Results Eight hundred strains were isolated, the positive rate was 53.9%.The most frequently isolated fungi were dermatophytes (84%), Trichophyton rubrum accounted for 80.9%, followed by Trichophyton interdigitale and Epidermophyton floccosum. The second was yeasts (11.4%), Candida accounted for 10.1%, mainly included C.parapsilosis, C.albicans and C.tropicalis.Non-dermatophytic moulds accounted for 4.6%, included Acremonium, Aspergillus, Penicillium, Chaetomium, Fusarium and Scopulariopsis.Conclusion In China, the most frequently pathogenic fungi of onychomycosis were dermatophytes, followed by yeasts and non-dermatophytic moulds.

Key words: onychomycosis, pathogenic fungi, multicenter, epidemiological survey

中图分类号:

R756.4

王爱平, 余进, 万喆, 李福秋, 曾敬思, 刘维达, 章强强, 郝飞, 冉玉平, 席丽艳, 赖维, 李若瑜. 国内多中心甲真菌病病原菌流行病学调查[J]. 中国真菌学杂志, 2015, 10(4): 197-202.

WANG Ai-ping, YU Jin, WAN Zhe, LI Fu-qiu, ZENG Jing-si, LIU Wei-da, ZHANG Qiang-qing, HAO Fei, RAN Yu-ping, XI Li-yan, LAI Wei, LI Ruo-yu. Multi-center epidemiological survey of pathogenic fungi of onychomycosis in China[J]. Chinese Journal of Mycology, 2015, 10(4): 197-202.

[1]	王玲, 景东云, 王学军, 刘俊, 曹月清. 长脉宽Nd:YAG 1064 nm激光治疗远端侧位甲下型甲真菌病的疗效观察及对真菌超微结构的影响[J]. 中国真菌学杂志, 2020, 15(5): 268-273.
[2]	方美珍, 刘钟, 江萍, 杨静, 董碧麟, 曾志良, 陈尊义, 童中胜. 湖北省及周边地区625例头癣病原菌分析[J]. 中国真菌学杂志, 2020, 15(5): 274-277.
[3]	步青云, 王润超, 罗亭, 卢昌佩, 景海霞. 甲真菌病的激光治疗新进展[J]. 中国真菌学杂志, 2020, 15(5): 310-313.
[4]	徐瑾, 何咏, 黄玲珍, 胡云峰, 吴实, 刘赛君, 邓列华. 荧光染色法、双重荧光染色法与KOH湿片法在甲真菌诊断中的比较研究[J]. 中国真菌学杂志, 2020, 15(3): 167-169,172.
[5]	刘洁, 刘晓云, 于波, 胡小平. 85株皮肤癣菌感染的病原菌分析及标准化体外药物敏感性研究[J]. 中国真菌学杂志, 2019, 14(6): 351-356.
[6]	刘文丽, 吴迪, 陈爱明, 苏万通, 鲍邦龙. 热带念珠菌致下肢皮肤感染1例并文献复习[J]. 中国真菌学杂志, 2019, 14(6): 369-370.
[7]	熊瑛, 陈婷, 柴宝, 曾飞鹏, 孙文文, 吴波. 不同激光不同能量对红色毛癣菌的体外抑制评估及部分机制的探讨[J]. 中国真菌学杂志, 2019, 14(5): 292-296.
[8]	曹艳云, 孙盈翡, 徐徉, 孔伟, 徐顺明. 长脉冲1064 nm激光联合酮康唑软膏封包病甲治疗甲真菌病的临床疗效观察[J]. 中国真菌学杂志, 2019, 14(3): 154-158.
[9]	吴先伟, 邓秀娥, 汪舰笛. 艾氟康唑治疗甲真菌病的疗效和安全性[J]. 中国真菌学杂志, 2019, 14(3): 180-182.
[10]	张天. 124例慢性肝硬化失代偿期患者感染病原菌特点及危险因素[J]. 中国真菌学杂志, 2018, 13(4): 235-238.
[11]	韦永刚, 颜红英, 肖远红. 老年慢性阻塞性肺疾病急性加重合并肺部感染的病原菌分布及高危因素分析[J]. 中国真菌学杂志, 2018, 13(3): 177-180,183.
[12]	宋娜娜, 周晓伟, 李筱芳, 刘维达. 甲真菌病外用药的治疗现状及研究进展[J]. 中国真菌学杂志, 2018, 13(3): 184-187.
[13]	王若珺, 李若瑜, 王爱平. 外用抗真菌药物治疗甲真菌病进展[J]. 中国真菌学杂志, 2018, 13(2): 114-119.
[14]	岳学苹, 石秀艳, 陈伟, 万喆, 李若瑜, 王爱平, 李清. CFW荧光染色法在甲真菌病诊断中的应用研究[J]. 中国真菌学杂志, 2018, 13(1): 8-10,45.
[15]	余菁, 马越娥, 史玉玲. 卫凤莲真菌感染检测方法的研究进展[J]. 中国真菌学杂志, 2017, 12(4): 252-256.