白念珠菌致病性研究进展

摘要/Abstract

摘要： 白念珠菌是一种重要的条件致病菌,多在体表及黏膜宿主共栖生存,可引起皮肤黏膜及内脏的广泛感染.白念珠菌是单细胞假菌丝酵母菌,形态上具有双相性,即菌丝相和孢子相.其中菌丝相更易黏附和入侵宿主组织,是该菌在体内的主要致病形式.白念珠菌的致病机制与多种因素如黏附、芽管、水解酶、生物膜、群体感应等有关.该文综述了白念珠菌致病机制的研究新进展.

关键词: 白念珠菌, 致病机制, 真菌

Abstract: Candida albicans is one of the most common fungal pathogens of humans that colonize the skin and mucosal surfaces of the healthy hosts. Candida albicans can cause the widespread infection in the skin mucous membrane and viscera of the hosts.This microorganism is the single cell pseudohyphae yeast,which can grow as both of yeast and filamentous forms in the host,and viscerarmed fungal dimorphism or,more precisely,fungal polymorphism.The relative attributes of the yeast and filamentous forms of Candida albicans,during the colonization of skin and mucosa,and later in the invasion of the blood stream and deep tissues,had long been debated.The pathogenesis of Candida albicans had been attributed to multi-factors,including adherence to host cells,secretion of degradative enzymes,morphology switching,successful biofilm formation,quorum sensing and so on.In this paper,the recent research progress in the pathogenesis of Candida albicans was reviewed.

Key words: Candida albicans, pathogenesis, fungus

中图分类号:

R379.4

朱丹婷, 李景, 俞立英. 白念珠菌致病性研究进展[J]. 中国真菌学杂志, 2015, 10(1): 54-58.

ZHU Dan-ting, LI Jing, YU Li-ying. Research progress in the pathogenesis of Candida albicans[J]. Chinese Journal of Mycology, 2015, 10(1): 54-58.

参考文献

[1] Williams,D W,Jordan,R P C,Wei,X Q,et al.Interactions of Candida albicans with host epithelial surfaces[J].J Oral Microbiology,2013,5:22434.
[2] 秦晓峰,吴建华,顾军.白念珠菌黏附基因研究进展[J].中国真菌学杂志,2006,1(3):186-189.
[3] Gropp K,Schild L,Schindler S,et al.The yeast Candida albicans evades human complement attack by secretion of aspartic proteases[J].Mol Immunol,2009,47(2/3):465-475.
[4] Villar CC,Kashleva H,Nobile CJ,et a1.Mucosal tissue invasion by Candida albicans is associated with E-cadherin degradation,mediated by transcription factor Rim101p and protease Sap5p[J].Infect Immun,2007,75(5):2126-2135.
[5] 仇萌,邹先彪.Sap2与侵袭性白念珠菌感染相关性研究进展[J].中国真菌学杂志,2012,7(1):52-54.
[6] 马虎,崔凡,林昭春,白念珠菌致病相关的水解酶[J].中国真菌学杂志,2012,7(4):247-251.
[7] Albrecht A,Felk A,Pichova I,et al.Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions[J].J Biol Chem,2006,281(2):688-694.
[8] Naglik JR,Rodgers CA,Shirlaw PJ,et al.Differential expression of Candida albicans secreted aspartyl proteinase and phospholipase B genes in humans correlates with active oral and vaginal infections[J].J Infect Dis,2003,188(3):469-479.
[9] Djordjevic J T.Role of phospholipases in fungal fitness,pathogenicity,and drug development lessons from Cryptococcus neoformans[J].Front Microbiol,2010,1:125.
[10] Diaz BL,Arm JP.Phospholipase A(2)[J].Prostaglandins Leukot Essent Fatty Acids,2003,69(2-3):87-97.
[11] Kunze D,Melzer I,Bennett D,et al.Functional analysis of the phospholipase C gene CaPLC1 and two unusual phospholipase C genes,CaPLC2 and CaPLC3,of Candida albicans[J].Microbiology,2005,151(10):3381-3394.
[12] Schaller M,Borelli C,Korting H C,et al.Hydrolytic enzymes as virulence factors of Candida albicans[J].Mycoses,2005,48(6):365-377.
[13] Paraje MG,Correa SG,Albesa I,et al.Lipase of Candida albicans induces activation of NADPH oxidase and L-arginine pathways on resting and activated macrophages[J].Biochem Biophys Res Commun,2009,390(2):263-268.
[14] Hube B,Stehr F,Bossenz M,et al.Secreted lipases of Candida albicans:cloning,characterisation and expression analysis of a new gene family with at least ten members[J].Arch Microbiol,2000,174(5):362-374.
[15] 钱丽洁章强强,白念珠菌芽管致病性的研究进展[J].中国真菌学杂志,2006,1(2):124-125,84.
[16] Cheng S,Clancy CJ,Checkley MA,et al.The role of Candida albicans NOT5 in virulence depends upon diverse host factors in vivo[J].Infect Immun,2005,73(11):7190-7197.
[17] 石婧,张宏.白念珠菌菌丝相和酵母相 ERG11基因部分序列差异性的探讨[J].中华皮肤科杂志,2004,37(8):472-474.
[18] Nair RG,Anil S,Samaranayake LP.The effect of oral bacteria on Candida albicans germ-tube for mation[J].APM IS,2001,109(2):147-154.
[19] Rodrigues AA,Pina-Vaz C,Mardh P A,et al.Inhibition of germtube for mation by Candida albicans by local anesthetics:an effect related to ionic channel blockade[J].Curr Microbiol,2000,40(3):145-148.
[20] Imanishi Y,Yokoyama K,Nishimura K.Inductions of germtube and hyphal formations are controlled by mRNA synthesis inhibitor in Candida albicans[J].Nippon Ishinkin Gakkai Zasshi,2004,45(2):113-119.
[21] Douglas LJ.Candida biofilms and their role in infection[J].Trends Microbiol,2003,11(1):30-36.
[22] Chandra J,Kuhn DM,Mukherjee PK,et al.Biofilm formation by the fungal pathogen Candida albicans:development,architecture,and drug resistance[J].J Bacteriol,2001,183(18):5385-5394.
[23] Popat R,Crusz S A,Diggle SP.The social behaviours of bacterial pathogens[J].BrMed Bull,2008,87(1):63-75.
[24] 车付彬,徐楠,陈江汉,病原真菌中群体感应现象研究进展[J].第二军医大学学报,2009,30(4):447-449.
[25] 王立霞,白念珠菌群体感应分子的研究现状[J].中国皮肤性病学杂志,2013,27(10):1055-1057.
[26] Langford M L,Hasi M S,Nickerson K W,et al.Activity and toxicity of farnesol towards Candida albicans are dependent on growth conditions[J].Antimicrob Agents Chemother,2010,54(2):940-942.
[27] Shirtliff ME,Krom BP,Meijerring RA,et al,Farnes ol induced apoptosis in Candida albicans[J].Antimicrob Agents Chem other,2009,53(6):2392-2401.
[28] Ramage G,Saville S P,Wickes B L,et al,Inhibition of Candida albicans biofilm formation by farnesol a quorum-sensing molecule[J].Appl Environ Microbiol,2002,68(11):5459-5463.
[29] Hisajima T,Maruyama N,Tanabe Y,et al,Protective effects of farnesol against oral candidiasis in mice[J].Microbiol Immunol,2008,52(7):327-333.
[30] Navarathna DH,Horrnby JM,Krishnan N,et al,Effect of farnesol on a mouse model of systemic candidiasis,determined by use of a DPP3 knock out mutant of Candida albicans[J].Infect Immun,2007,75(4):1609-1618.