念珠菌血症与血小板减少症

中国真菌学杂志　 2014, Vol. 9 　Issue (5): 303-306.

念珠菌血症与血小板减少症

1. 中国人民解放军白求恩国际和平医院检验科, 石家庄 050082;
2. 中国人民解放军66131部队卫生队, 保定 071100;
3. 河北医科大学免疫教研室, 石家庄 050017

收稿日期:2014-04-12 出版日期:2014-10-28 发布日期:2014-10-28
作者简介:侯天文, 男 (汉族), 硕士, 主任技师, 硕士研究生导师. E-mail:houtw2013@163.com
基金资助:
河北省自然科学基金项目(C2010001882)

Received:2014-04-12 Online:2014-10-28 Published:2014-10-28

摘要/Abstract

摘要： 念珠菌血症常常出现血小板减少,甚或呈现血小板减少症.本文就目前有关念珠菌与血小板相互作用文献作一综述.发生念珠菌血症时,血小板可通过纤连蛋白等黏附于念珠菌,激活后释放α颗粒中多种抗真菌物质,引起细胞膜破坏和崩解,封闭和或延迟真菌芽管产生和菌丝延长,有效地抑制真菌早期阶段生长.而念珠菌依靠自身结构成份和代谢产物抑制血小板聚集,促进念珠菌扩散.因此,血小板抗念珠菌免疫损耗是念珠菌血症出现血小板减少现象的内在机制,早期检测血小板活化标志物CD42a和PAC1,将有助于念珠菌血症的早期诊疗.

中图分类号:

R519.3

侯天文, 崔庆廷, 陈礼平, 尹晓琳, 郑运周. 念珠菌血症与血小板减少症[J]. 中国真菌学杂志, 2014, 9(5): 303-306.

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